MALDES

Typical gas phase ionisation methods (vaporisation followed by ionisation) are El, Cl, FI, MPI desorption/ionisation methods for nonvolatile samples (ions formed in the condensed phase) are FD, PD, SIMS, FAB, DCI, TSP, LD-SIMS, MALD, ESP/ISP. 

For non-volatile sample molecules, other ionisation methods must be used, namely desorption/ionisation (DI) and nebulisation ionisation methods. In DI, the unifying aspect is the rapid addition of energy into a condensed-phase sample, with subsequent generation and release of ions into the mass analyser. In El and Cl, the processes of volatilisation and ionisation are distinct and separable in DI, they are intimately associated. In nebulisation ionisation, such as ESP or TSP, an aerosol spray is used at some stage to separate sample molecules and/or ions from the solvent liquid that carries them into the source of the mass spectrometer. Less volatile but thermally stable compounds can be thermally vaporised in the direct inlet probe (DIP) situated close to the ionising molecular beam. This DIP is standard equipment on most instruments an El spectrum results. Techniques that extend the utility of mass spectrometry to the least volatile and more labile organic molecules include FD, EHD, surface ionisation (SIMS, FAB) and matrix-assisted laser desorption (MALD) as the last... 

M. Kjellevold Malde, K. Bjorvatn, K. Julshamn, Determination of fluoride in food by the use of alkali fusion and fluoride ion-selective electrode, Food Chem. 73 (2001) 373-379. 

M. C. Huberty, J. E. Vath, W. Yu, and S. A. Martin, Site-specific carbohydrate identification in recombinant proteins using MALD-TOF MS, Anal. Chem., 65 (1993) 2791-2800. 

Nayyar A, Malde A, Coutinho E, Jain R (2006) Synthesis, anti-tuberculosis activity, and 3D-QSAR study of rmg-substituted-2/4-qui-nolinecarbaldehyde derivatives. Bioorg Med Chem 14 7302-7310... 

S. Snigyr, T. Gromovoy, V. Pokrovskiy, and A. Chuiko. MALD TOF mass spectrometry of fullerene C60 on silicon and steel targets, Abstr. International Conference Nanomaterials in Chemistry, Biology and Medicine (September 15-16, 2005. Kiev, Ukraine), p. 123. 

Kaufinann, R. Wingerath, T. BCirseh, D. Stahl, W. Sies, H. 1996. Analysis of carotenoids and earotenol fatty aeid esters by matrix-assisted laser desorption ionization (MALDI) and MALD-post-source-decay mass speetrometry. Anal. Biochem. 238 117-128. 

BMCL1403 A.K. Chakraborti, B. Gopalakrishnan, M.E. Sobhia, A. Malde, Bioorg. Med. Chem. Lett. 2003,... 

Malde, H., Nagral, A., Shah, R, Joshi, M.S., Bhatia, S.J., Abraham, R Detection of rectal and pararectal varices in patients with portal hypertension efficacy of transvagjnal sonograp%. Amer. J. Roentgenol. 1993 161 335-337... 

Pike KJ,Malde RRAshbrook SE, McManus J, Wimperis S (2000) Solid State Nucl Magn Reson 16 203... 

Commissioning Editor Maria Khan Managing Editor Rupal Malde Production Editor Fiona Pattison Production Controller Kate Charman... 

The molecular weight of polymer was estimated by MALD-TOF MS (Fig. 11). The peaks show exactly the molecular masses of the polymers. The glass transition temperature (Tg) of the polymers obtained from DEF 6 and DEM 7 are almost identical. The effective CD-mediated homopolymerization reactivity of 6a and 7a are visualized in Fig. 12. The uncomplexed monomers 6 and 7 did not polymerize under the same conditions. 

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