Mass post-source decay

Matrix-assisted laser desorption ionization post-source-decay mass spectrometry... 

Post-source decay The term used to describe the production of product-ion MS-MS spectra in a time-of-flight mass analyser. 

Both collisional activation (in ion traps) and post source decay (in curved field reflectron TOF analyzers) have been used successfully to obtain sequence ions from peptides prepared in situ on the sample holder. Single Dalton mass windows are advantageous for precursor selection, as are realized in ion-trap and trap-TOF configurations. Publicly available search algorithms can be used... 

Figure 6 Partial MALDI-TOF mass spectrum from PMMA generated by ATRP with ethyl-2-bromoisobutyrate as initiator (inset shows theoretical isotope distribution for lithiated 18-mer of structure 3). (Peak labelled 3 arises from post-source decay of 3 [10].)...

B. Spengler. Post-Source Decay Analysis in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry of Biomolecules. J. Mass Spectrom., 32(1997) 1019-1036. 

The development glycopeptide libraries obtained by the split-mix method is severely hampered by the lack of concurrent development of a general, facile separation and characterization technology. Some headway has been made with chemical coding of the libraries, but very few direct methods of analysis exist. One promising method that could be applied to the direct characterization of both types of libraries is mass spectrometry. More specifically, post-source-decay matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (PSD-MALDI-TOF-MS) and CID-FAB/MS/MS have been used to characterize glycopeptides.53-55... 

PAGE Phe Pro PSD QC Q-ToF Q-ToF-LC-MS-MS polyacrylamide gel electrophoresis phenylalanine proline post-source decay quality control quadrupole time-of-flight mass analyser quadrupole time-of-flight mass analyser in combination with (high performance) liquid chromatography and tandem mass... 

Several original papers must be mentioned that deal with mass spectrometric techniques which the numerous reviews do not comprise. Kaufmann and coworkers268,288 studied the mass spectrometric analysis of carotenoids and some of their fatty acid esters using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry and its post-source-decay (PSD) variant. Some advantages concerning the thermal instability and limited solubility were discussed, but the fragmentation paths of the carotenoid cations were found to be essentially the same as those observed with conventional techniques. 

Cordero, M.M. Cornish, T.J. Cotter, R.J. Lys, LA. Sequencing Peptides Without Scanning the Reflectron Post-Source Decay With a Curved-Field Reflectron TOF Spectrometer. Rapid Commun. Mass Spectrom. 1995, 9, 1356-1361. 

Spengler B (2001) The basics of matrix-assisted laser desorption ionization time-of flight mass spectrometry and post source decay. In James P (ed) (2001) Proteome research Mass spectrometry. Springer, New York, p 33... 

Keki, S., Deak, G., and Zsuga, M., Fragmentation study of rutin, a naturally occurring flavone glycoside cationized with different alkali metal ions, using post-source decay matrix-assisted laser desorption/ionization mass spectrometry, J. Mass Spectrom., 36, 1312, 2001. 

Kaufmann, R., Wingerath, T., Kirsch, D., Stahl, W., and Sies, H. 1996. Analysis of carotenoids and carotenol fatty acid esters by matrix-assisted laser desorption ionization (MALDI) and MALDI-post-source-decay mass spectrometry. Anal. Biochem. 238 117-128. 

Peptide sequencing via post-source decay and tandem mass spectrometry. 339... 

Spengler, B. (1 997) Post-source decay analysis in matrix-assisted laser desorption/ionization mass spectrometry of biomolecules. Journal of Mass Spectrometry 32, 1019-1036. 

B. Spengler, D. Kirsch, R. Kaufmann, and J. Lemoine, Structure analysis of branched oligosaccharides using post-source decay in matrix-assisted laser desorption ionization mass spectrometry, Org. Mass Spectrom., 29 (1994) 782-787. 

Kaufmann R, Chaurand P, Kirsch D, Spengler B. Post-source decay and delayed extraction in matrix-assisted laser desorption/ionization-reflectron time-of-flight mass spectrometry. Are there trade-offs . Rapid Commun Mass Spectrom 1996 10 1199-1208. 

Kaufmann, R., Kirsch, D., and Spengler, B. (1994). Sequencing of peptides in a time-of flight mass spectrometer Evaluation of post source decay following matrix-assisted laser desorption ionization (MALDI). Int. ]. Mass. Spectrom. Ion Processes 131, 355-385. 

B. SPENGLER, D. KIRSCH and R. KAUFMANN obtain structural information with reflectron TOF mass spectrometry (MALDI post-source decay) [66],... 

Positive Ion Chemical Ionization Photo-Induced Dissociation Post-Source Decay Pyrolysis Mass Spectrometry Quadrupole device used in RF-only mode Quadrupole... 

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