Malarial fever

A) Aniline is an aromatic amine that is useful for preparing dyes. (B) Adrenaline is a hormone that is produced hy the human body when under stress. (C) Quinine is an effective drug against malarial fever. 

Mussaenda parviflora Miq. Yu Ye Jin Hua (leaf, root) Triterpinoid.79 Treat malarial fever. 

N.A. Alkaloids, rescrpine.99 This herb is toxic. Treat malarial fever, antispasmodic, lower blood presure, reduce high blood pressure. 

The true scientific era of the salicylates began in England in 1763, when the Reverend Edward Stone presented a report to the Royal Society on the use of willow bark as a fever treatment. Stone was a believer in the rather curious Doctrine of Signatures, which maintained that one could find cures where the diseases themselves were spawned. Since fevers were often associated with swamps, probably because of mosquito-borne infectious agents, Stone searched swamplands for cures. He tasted a sprig of willow and was stunned by its bitterness. Aware that quinine, an equally bitter substance, was useful in the treatment of malarial fever. Stone decided to give willow... 

The suppression of malarial fever by quinine is etiological. However, quinine also reduces other febrile temperatures to normal, analogous to the other antipyretic drugs, i.e., by adjustment of the temperature-regulating centers, primarily through increased heat loss, assisted somewhat by diminished heat production. 

FIGURE 6.2. Incidents of Illness per 1,000 White and BlackTroops, Union Army Source The Medical and Surgical History of the War of the Rebellion, Part 3, Volume 1, Medical Volume [Washington GPO, 1888], pp. 6-77 passim. The figure for camp fevers is a compilation of continued, typho-malaria, and malarial fevers. See George Worthington Adams, Doctors in Blue, p. 240). 

Achyranthes aspera (family Amaranthaceae) is an indigenous medicinal plant of Asia and is commonly used by traditional healers for the treatment of malarial fever, dysentery, asthma, hypertension and diabetes (Girach and Khan, 1992). A root extract is also used to treat scorpion and snake bites by Indian tribes. A typical yellows and small leaves symptoms... 

Haiti cure of malarial fever Timyan, 1996, cited in (3)... 

Snakebite, wounds Diarrhea, dysentery, cough, asthma, rheumatic fevers, wounds Heart diseases, catarrah, eye diseases Malarial fever... 

The historical importance and utility of quinine was known in the medical practice for a long time as a potent antipyretic in addition to its remarkable effect against the malarial fever. The basic quinoline nucleus, present in the quinine molecule, contributes to antipyretic activity to a certain extent. Therefore, an attempt was made to synthesize a number of quinoline derivatives which might exhibit better antipyretic activity. 

A kidney transplant patient taking ciclosporin, azathioprine and prednisolone had a threefold rise in ciclosporin blood levels, from 148 to 420 nanograms/mL, accompanied by a rise in serum creatinine levels within 48 hours of starting chloroquine 900 mg daily for suspected malarial fever. On days 2 and 3 the ehloroquine dosage was reduced to 300 mg daily. The eielosporin and ereatinine returned to their former levels 7 days... 

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