Malarial fever against

A) Aniline is an aromatic amine that is useful for preparing dyes. (B) Adrenaline is a hormone that is produced hy the human body when under stress. (C) Quinine is an effective drug against malarial fever. 

The historical importance and utility of quinine was known in the medical practice for a long time as a potent antipyretic in addition to its remarkable effect against the malarial fever. The basic quinoline nucleus, present in the quinine molecule, contributes to antipyretic activity to a certain extent. Therefore, an attempt was made to synthesize a number of quinoline derivatives which might exhibit better antipyretic activity. 

Artemisinin, the principal bioactive antimalarial compound and its derivatives from Artemisia annua, a Traditional Chinese Medicinal plant used against fevers and malaria, have yielded a potent new class of antimalarials. The anti-malarials derived from A. annua are considered an integral part of the solution where malaria has become resistant to other medicines and even in areas where resistance is not yet a problem (S). Artemisinin-based combination therapies (ACTs) have been recommended in the countries where falciparam malaria - the most resistant form of the disease- is endemic (9). While ACTs for all would be the ideal strategy, it is most impractical for poor and remote communities, politically unstable areas, and people who dislike the use of modem medicine (10). 

In 1978, WHO announced that it was extensively using chlorpyriphos and fenthion to control the Culex mosquito vector of filariasis these are respectively 0,0 -diethyl O" -(3,5,6-trichloropyrid-2-yl) phosphorothioate and 0,0 -dimethyl 0"-(3-methyl-4-methylthiophenyl) phosphorothioate. Against Aedes mosquitoes, carriers of dengue and yellow fever viruses, they were using temephos 0,0 -(thiodi-4,i-phenylene) 0,0,0, 0 -tetramethyl phosphorothioate. To supplement their control of anopheline mosquitoes (vectors of the malarial parasites) they had introduced brom-ophos, iodfenphos, and pirimiphos-methyl, which are respectively 0-(4-bromo-2,5-dichlorophenyl) 0, 0"-dimethyl phosphorothioate ... 

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