Magnolol from

Xu, Q., Yi, L. T., Pan, Y., Wang, X., Li, Y. C., et al. (2008) Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents. Prog Neuropsychopharmacol Biol Psychiatry 32, 715-725. 

Dean JR, Liu B, Price R. Extraction of magnolol from Magnolia officinalis using supercritical fluid extraction and phytosol solvent extraction. Ph5dochem Anal 1998 9 248-252. 

Various reports on the antihypertensive activity of lignans were published before 1997 [14], ( )-Pinoresinol diglucoside from Eucommia ulmoides (Eucommiaceae), pinoresinol monoglucoside from Forsythia spp., sesamin from sesame oil, neojusticin B from Justicia procumbens, ephedradine B (a hybrid neolignan-alkaloid) from Ephedra spp.(Ephedraceae), danshensuan B from Salvia miltiorrhiza (Labiatae) and magnolol from different sources were all reported to be hypotensives in different animal models. 

Lo YC, Teng CM, Chen CF, Magnolol and honokiol from Magnolia officinalis protect tat heatt mitochondria against lipid petoxidation, Biochem Pharmacol... 

Magnolol is a bioactivator extracted from Magnolia officinalis with protective effects on cholinergic neurons. Magnolol restores the impaired abilities of learning and memory induced by scopolamine, and AChE, NOS, and SOD activities in mice [277]. 

Three compounds possessing neurotrophic activity were characterized from the root bark of M obovata Thunb. [51-53]. Three novel sesquiterpene neolignans, eudesobovatol A (33), clovane magnolol (34), and caryolanemagnolol (35) not only augment neurite sprouting, but also... 

Medicines containing the M. obovata bark have been prescribed as stomachic, diuretic, and antiemetic treatments. Both magnolol and honokiol were determined to be antiemetic in frogs [5]. Other sources of these compounds have been from M. henryii [58] and M. watsonii [59]. 

Using an experimental restenosis animal model of dietary-induced hypercholesterolemia combined with balloon injury of abdominal aortas, we demonstrated in this series of studies that antioxidants from the traditional herb medicines, magnolol (36), SM (37), and EGb (38), could attenuate the intimal response to balloon injury in cholesterol-fed rabbits by inhibiting intimal hyperplasia in abdominal aortas. In addition, these antioxidant treatments also markedly decreased atherosclerotic lesion areas in thoracic aortas without endothelial denudation. 

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