Magnesium calcium absorption/metabolism

Quinolones Group toxicity agents in this group are malabsorbed in the presence of magnesium, calcium, alum absorption theophylline metabolism is impaired higher oral doses may be needed to treat CAPD inum, and iron photosensitivity, food, dairy products, tube feeding, may also impair aeritonitis ... 

Warfarin The exact warfarin-quinolone drug interaction is unknown. Reduction of intestinal flora responsible for vitamin K production by antibiotics is probable, as are deaeased metabolism and clearance of warfarin due to CYP450 inhibition by the quinolones. Multivalent cations such as aluminum, magnesium, calcium, iron, zinc, and multivitamins with minerals may chelate with fluoroquinolones and decease the oral absorption if administered concurrently. 

Copper is recognized as an essential metalloelement like sodium, potassium, magnesium, calcium, iron, zinc, chromium, vanadium and manganese [1]. Like essential amino acids, essential fatty acids and essential cofactors (vitamins), essential metalloelements are required for normal metabolic processes but cannot be synthesized de novo and daily dietary intake and absorption are required. The adult body contains between 1.4 mg (22 pmol) and... 

These studies have shown that phosphorus, magnesium and fluoride In the doses used had no effect on the bloavailablllty of calcium, while large doses of zinc given during a low calcium Intake Inhibited the Intestinal absorption of calcium The effect of protein and of certain drugs on calcium metabolism Is also described ... 

Antibiotics. Long-term administration of antibiotics could lead to vitamin B6 deficiency, If symptoms of peripheral neuropathy develop (numbness and tingling of the extremities), administer vitamin B6. Sulfasalazine can decrease the absorption of folic acid, and trimethoprim can cause folate deficiency, hence the need to administer folic acid if there is evidence of deficiency. Rifampicin can cause disturbances in vitamin D metabolism and lead to osteomalacia. The absorption of tetracyclines can be reduced by calcium, magnesium, iron and zinc, while this antibiotic could also decrease the absorption of these minerals. This effect is probably least with minocycline and is not confirmed with doxycycline. Doses of minerals and antibiotic should be separated by at least 2 hours. The absorption of quinolones is reduced by cationic and anionic supplements. 

Hunt, C. D., Herbel, J., and Nielsen, E H. (1997). Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium Intake Boron, calcium, and magnesium absorption and retenton and blood mineral concentrations. Am. /. Cfin. Nuir, 65, 803-813. 

The absorption of tetracyclines from the G1 tract is non-uniform. Up to 30% of chlortetracycline is absorbed. The absorption for tetracycline, oxytetracycline, and demeclo-cycline ranges between 60 and 80%, whereas as much as 90 to 100% of doxycycline and minocycline is absorbed. The absorption of tetracyclines is impaired by divalent cations (calcium, magnesium, and ferrous iron), by aluminum, and by extremely alkaline pHs. Tetracyclines are distributed widely throughout the body fluid, cross the placental barrier, and can accumulate in growing bones. The concentrations of chlortetracycline in spinal fluid are only one fourth of those in plasma. Minocycline, a more lipid-soluble tetracycline, reaches a high concentration in tears and saliva and can eradicate the meningococcal carrier state. The tetracyclines are metabolized in the liver and excreted mainly by the bile and urine. The concentrations of tetracyclines in the bile are ten times higher than those in serum. 

OxaKc add HOOC-COOH. O.a. occurs widely in plants as its caldum, magnesium and potassium salts. By forming insoluble calcium salts in the intestine, it hinders the absorption of caldum. It is not metabolized by animals, and in large quantities it is poisonous. Humans normally excrete 10-30mg O.a. daily higher levels may lead to kidney damage (formation of oxalate kidney stones). 

Calcium (Ca ) Parathyroid hormone Calcitonin Magnesium (helps in calcium metabolism and intestinal absorption) Intestinal absorption Renal reabsorption Renal excretion... 

The absorption of calcium, sodium, potassium, chloride, magnesium, and iron is thought to be influenced by the thyroid hormone. The results of the studies of the effect of thyroxine on electrolyte metabolism are often contradictory and difficult to interpret however, it seems accepted that thyroxine affects phosphorus metabolism by increasing the excretion of the metal in both urine and stools. 

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