Magainin derivatives

It was previously suggested in the literature that a comparison between new compounds and a reference peptide would be the best indicator for clinical cytotoxicity, and allow a better comparison between different antibacterial agents from different laboratories 72). In a control experiment, the activity of a Magainin derivative (MSI-78), a well-known antimicrobial peptide, was measured against the same E. coli strain. In comparison to above described... 

Broad Spectrum Antifungal Activity. The natural magainins 1 and 2 exhibited similar activities against a number of important plant pathogens (Table II). Colletotrichum and Phytophthera represented two fungal species that appeared to be resistant to magainins 1 and 2, but which were weakly sensitive to two synthetic magainin derivatives (Table II MYPs 20 and 21). The results obtained with... 

The magaiitins are a class of hnear, cationic, faciaUy amphipathic and hehcal antibacterial peptides derived from frog skin [51]. The magaiitins exhibit highly selective and potent antimicrobial activity against a broad spectrum of organisms [52, 53]. As these peptides are faciaUy amphipathic, the magainins have a cationic heli-... 

Anticancer squalamine and derivs/steroidal alkal. OSOjH marine Squalus acanthias L., Ch[Pg.163]

BPI (86-99) KISGKWKAQKRFLK (smallest BPI -derived peptide found to bind LPS) magainin GIGKFLHSAGKFGKAFVGEIMKS... 

To qualitatively investigate the effect of altering the amount of magainin I grafted onto the copolymer brush surface, the brushes were functionalised with a biotin-tagged derivative (biotinyl-MAG-Cys) and then incubated with streptavidin-fluorescein isothiocyanate (streptavidin-FITC) the surface-immobilised streptavidin-FITC... 

Antimicrobial Activity. The natural magainins and some synthetic derivatives have been shown to have relatively broad spectrum activity against a wide range of pathogens (9,10) including important plant pathogens such as Cercospora spp, Cochliobolus spp., Fusarium spp., Pythium spp., Trichoderma spp., Verticillium spp., Erwinia spp.. Pseudomonas spp. and Xanthomonas spp. (Everett et al., unpublished). 

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