Macrophage cytotoxicity activation

I IS. Hibbs-. B, Taintor, R. R., Vavrm, Z., and Rachlin, E. M. (1988). Nitric oxide A cytotoxic activated macrophage effector molecule. Biochem. Biophys. Res. Commun. 1.57, 87-99,... 

TNF-a is also known as cachectin, macrophage cytotoxic factor, macrophage cytotoxin and necrosin. As some of these names suggest, activated macrophages appear to represent the most significant cellular source of TNF-a, but it is also synthesized by many other cell types (Table 9.5). Producer cells do not store TNF-a, but synthesize it de novo following activation. 

Catectin promotes tumor cytotoxicity activates macrophages and neutrophils enhances IL-2 receptor expression on T cells inhibits antibody secretion... 

Li, W., Yuan, X.M., Brunk, U.T., 1998b, OxLDL-induced macrophage cytotoxicity is mediated by lysosomal rupture and modified by intralysosomal redox-active iron, Free Radio. Res. 29 389-398. 

Interferon gamma is an activator of macrophages. Its anti-viral activity is limited compared to that of interferon alfa. Human recombinant interferon gamma restores, at least in part, macrophage cytotoxicity and with that decreases the incidence of infections in patients with chronic granulomatous diseases. Its adverse effects consist mainly of flu-like syndrome skin rashes may occur. 

Jones, 1971), and it is now known that these cytotoxic activated macrophages (CAMs) can be formed in vitro from macrophages by a combination of two signals, usually interferon-y and lipopolysaccharide (a major component of the cell wall of gram-negative bacteria). 

Drapier, J. C., and Hibbs, J. B., Jr. (1986). Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible. J. Clin. Invest. 78, 790-797. 

Lancaster, J. R., and Hibbs, J. B. (1990). EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Proc. Natl. Acad. Sci. LJ.S.A. 87, 1223-1227. 

CTM = cytotoxic activity against mouse macrophage cell line (RAW 264.7) [167] ... 

Furthermore, certain cells such as cytotoxic T lymphocytes and macrophages have Fc receptors, which bind to the Fc portion of the bound antibodies (e.g., IgG). As a result, the cytotoxic T cell or macrophage is activated, and lyses the cell to which the antibody is bound. 

Increased the cytotoxic activity of lung macrophages enhanced by OK-432 in rat 619... 

Depress cytotoxic activity of macrophages (increase incidence of cancers)... 

Interferon gamma binds to different cell surface receptors than alpha and beta Specific effect of interferon gamma include enhancement of oxidative metabolism of macrophages, antibody-dependent cellular cytotoxicity, activation of natural killer cells, and expression of Fc and major histocompatibility antigens While all alpha interferon have similar biological effects, not all activities shared by each and in many cases the extent of activity various substantially for each interferon subtype... 

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