M-Cadherin

Takeichi, M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 25 1451-1455,1993. 

Takeichi, M. Cadherins in cancer implications for invasion and metastasis. Curr. Opin. Cell Biol. 5 806-811,1993. 

Recently, several novel members of the cadherin family have been discovered M-cadherin in mouse embryonic skeletal muscle [35,36], R-cadherin in neuronal cells [37] and T-cadherin in myoblasts [38]. The structure of T-cadherin (Fig. 4) is of special interest. This cadherin in its mature form lacks the transmembrane and cytoplasmic domains of classical cadherins and is integrated into the membrane by a GPl anchor. Although T-cadherin is a severely truncated form and additionally lacks an HAV sequence in the El domain it appears to be functional. Transfection of cDNA encoding T-cadherin into a cell devoid of cadherin expression confers calcium-dependent aggregation on the cells [38]. The mechanism of T-cadherin adhesion is intriguing and presumably is independent of interactions with catenins and direct coupling with actin filaments. 

Fujita Y, Krause G, Scheffner M et al (2002) Hakai, a c-Cbl-like protein, ubiquitinates and induces endo-cytosis of the E-cadherin complex. Nat Cell Biol 4(3) 222-231... 

Troyanovsky, R.B., Sokolov, E.P., and Troyanovsky, S.M. (2006) Endocytosis of cadherin from intracellular junctions is the driving force for cadherin adhesive dimer disassembly. Mol. Biol. Cell 17, 3484-3493. 

Boggon, T. J., Murray, J., Chapuis-Flament, S., Wong, E., Gumbiner, B. M. and Shapiro, L. C-cadherin ectodomain structure and implications for cell adhesion mechanisms. Science 296(5571) 1308-1313, 2002... 

Fannon, A M. and Colman, D. R. A model for central synaptic junctional complex formation based on the differential adhesive specificities of the cadherins. Neuron 17 423 34,1996. 

Uchida, N., Honjo, Y., Johnson, K. R., Wheelock, M. J. and Takeichi, M. The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones. /. Cell Biol. 135 767-779,1996. 

Matasunaga, M., Hatta, K., Nagafuchi, A. and Takeichi, M. Guidance of optic nerve fibers by N-cadherin adhesion molecules. Nature 334 62-64,1988. 

Fannon,A.M.,Sherman,D.L.,Ilyina-Gragerova,G.,Brophy, P. J., Friedrich, V. L. Jr and Colman, D. R. Novel E-cadherin mediated adhesion in peripheral nerve Schwann cell architecture is stabilized by intracellular signals elicited by autotypic adherens junctions. J. Cell Biol. 129 189-202, 1995. 

Mengaud, J., Ohayon, H., Gounon, P., Mege, R.-M., and Cossart, P. (1996). E-cadherin is the receptor for intemalin, a surface protein required for entry of L. monocytogenes into epithelial cells. Cell 84, 923-932. 

Osada T, Sakamoto M, Ino Y, Iwamatsu A, Matsuno Y, Muto T et al (1996). E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma. Hepatology 24 1460-1467. 

Armicotte, J.S., lankova, 1., Miard, S., Fritz, V., Sarruf, D., Abella, A., Berthe, M.L., Noel, D., Pillon, A., Iborra, F., Dubus, P., Maudelonde, T., Culine, S. and Fajas, L. (2006) Peroxisome proliferator-activated receptor gamma regulates E-cadherin expression and inhibits growth and invasion of prostate cancer. Molecular and Cellular Biology, 26, 7561-7574. 

Miner P, Lampe P, Atkinson M, Johnson R Extracellular calcium and cadherins regulate the process of gap junction assembly between cells in culture in Kanno Y, Kataoka K, Shiba Y, Shibata Y, Shimazu T (eds) Intercellular Communication through Gap Junctions. Progress in Cell Research, vol 4. Amsterdam, Elsevier, 1995, pp 331-334. 

Steinberg, M.S. Takeichi, M. (1994). Experimental modification of cell sorting, tissue spreading and specific spatial patterning by quantitative differences in cadherin expression. Proc. Nat. Acad. Sci. USA, 91,206-209. 

Ray S, Chattopadhyay N, Mitra A, Siddiqi M, Chatterjee A. 2003. Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and E-cadherin. J Environ Pathol Toxicol Oncol 22 49-58. 

Troyanovsky, S. M., Eshkind, L. G., Troyanovsky, R. B., Leube, R. E., and Franke, W. W. (1993). Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage. Cell 72, 561-574. 

Carmeliet, R, Lampugnani, M. G., Moons, L., Breviario, F., Compemolle, V., et al. 1999b. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 98 147-157. 

Lin, M. T., Yen, M. L., Lin, C. Y., and Kuo, M. L. 2003. Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of Src-dependent vascular endothelial cadherin tyrosine phosphorylation. Mol. Pharmacol. 64 1029-1036. 

Weis, S., Shintani, S., Weber, A., Kirchmair, R., Wood, M., et al. 2004. Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction. J. Clin. Invest. 113 885-894. 

Zanetti, A., Lampugnani, M. G., Balconim, G., Breviariom, F., Corada, M., et al. 2002. Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling. Arterioscler. Thromb. Vase. Biol. 22 617-622. 

Lewis, J.E., Jensen, P.J., and Wheelock, M J., Cadherin function is required for human keratinocytes to assemble desmosomes and stratify in response to calcium, J. Invest. Dermatol., 102, 870, 1994. 

Wheelock, M.J., and Jensen, P.J., Regulation of keratinocyte intercellular junction organization and epidermal morphogenesis by E-cadherin, J. Cell Biol., 117, 415, 1992. 

Takeichi M. Morphogenetic roles of classic cadherins. Curr Opin Cell Biol. 1995 7 619-627. 

Redies, C. and Takeichi, M. 1996. Cadherine in the developing central nervous system an adhesive code for segmental and functional subdivisions. Developmental Biology, 180,413-423. 

C2. Campbell, M. J., Elstner, E., Holden, S., Uskokovic, M., and Koeffler, H. P., Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafloride vitamin D3 analogue involves the induction of p21 wafl, p27kip and E-cadherin. J. Mol. Endocrinol. 19, 15-27 (1997). 

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