Cadherins/Catenins

Yet another family of junction adhesion molecules (JAMs) was recently located at the tight junctions of both endothelial and epithelial cells. The intracellular domain of JAM-1 also interacts with structural and signaling proteins, such as ZO-1 and cingulin. Lastly, the molecular organization of the endothelial cell junctions includes two other cell-cell contact Ca2+-dependent cadherin-catenin systems. These make up the adherens junction common to all endothelial cell junctions. 

Tabibzadeh S, Babaknia A, Kong QF, Zupi E, Marconi D, Romanini C, and Satyaswaroop PG [1995] Menstruation is associated with disordered expression of desmoplakin I/II and cadherin/catenins and conversion of F- to G-actin in endometrial epithelium. Hum Reprod 10 776-784... 

Aberle, H., Schwartz, H., and Kemler, R. 1996. Cadherin-catenin complex protein interactions and their implications for cadherin function. J. Cell. Biochem. 61 514—523. 

Ronzitti, G., Callegari, E, Malaguti, C., and Rossini, G. P. 2004. Selective disruption of the E-cadherin-catenin system by an algal toxin. BrJ Cancer 90, 1100-1107. 

Staddon, J.M., Smales, C., Schulze, C., Esch, F.S., Rubin, L.L. (1995). pl20, a pl20-related protein (plOO), and the cadherin/ catenin complex. J. Cell. Biol. 130 369-81. 

Yessotoxins 14 are produced by dinoflagellates of the genera Protoceratium and Gonyaulax. They canse selective disrnption of the E-cadherin-catenin system in epithelial cells (11). In common with the other ladder shaped marine polyethers, yessotoxin interacts with transmembrane helix domains. 

ZImmerhackI LB, Momm F, WIegele G, and Brandis M. Cadmium Is more toxic to LLC-PKl cells than to MDCK cells acting on the cadherin-catenin complex. Am J Physiol 275 FI43-153,1998. 

Bracke ME, Van Roy FM, Mareel MM. The E-cadherin/catenin complex in invasion and metastasis. Curr Top Microbiol Immunol. 1996 213(Pt 1) 123-161. 

Gooding JM, Yap KL, Ikura M. The cadherin-catenin complex as a focal point of cell adhesion and signalling New insights from three-dimensional structures. Bioessays. 2004 26 497-511. 

Shibamoto S, Hayakawa M, Takeuchi K, et al. Association of pl20, a tyrosine kinase substrate, with E-cadherin/catenin complexes. / Ce//Bio/. 1995 128 949-957. 

Berx G, Van Roy F. The E-cadherin/catenin complex An important gatekeeper in breast cancer tirmorigenesis and malignant progression. Breast Cancer Res. 2001 3 289-293. 

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