Lymphopenia, induced

Bone marrow toxicity Peginterferon alfa-2a suppresses bone marrow function and may result in severe cytopenias. Ribavirin may potentiate the neutropenia and lymphopenia induced by alpha interferons including peginterferon alfa-2a. Alpha interferons may be associated with aplastic anemia very rarely. 

Blum A, Shohat B. CD-4 lymphopenia induced by streptokinase. Circulation 1995 91(6) 1899. 

Zemann, B., Kinzel, B., Muller, M., Reuschel, R., Mechtcheriakova, D., Urtz, N., Bornancin, F., Baumruker, T., Billich, A. Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood 107 (2006) 1454-1458. 

Craddock CG. Corticosteroid-induced lymphopenia, immunosuppression, and body defense. Ann Intern Med 1978 88(4) 564—6. 

Any immune manipuladon, which acdvates the immune system to induce a well-cond olled increase in the likelihood that relevant T cells will home to a site of injury site, can be expected to be beneficial. Three major approaches could be considered immunizadon with self-andgen agonists, induc-don of lymphopenia or funcdonal inacdvadon of naturally occurring regulatory CD4 CD25 T cells. 

Vlachonikolis J, Georgoulias V. Docetaxel-induced lymphopenia in patients with solid tumors a prospective phenotypic analysis. Cancer 2000 89(6) 1380-6. 

Anacardium occidentale L. (leaves). Cashew plant. Agathisflavone (100). Cytotoxic activity. An ethanolic extract elicited lymphopenia in rats, and induced apoptosis in Jurkat cells. Agathisflavone (100) showed a high anti-proliferative effect in Jurkat cells (IC50 = 4.45 pM). Agathisflavone induced apopto.sis in Jurkat cells. Konan et al., 2010 [45]. 

Tumorigenicity Fumaric acid esters have been used in the treatment of psoriasis since 1959, after Schweckendiek s description. They induce a shift from the T-helper 1 (Th-1) cytokine response to a Th-2 cytokine response and subsequent lymphopenia with low CD3 and CD4 counts. Low CD4 counts reflect the degree of immunosuppression and, in organ transplant recipients increase the risk of skin cancers, such as squamous cell carcinoma [25 ]. 

Raj V, Druitt T, Purushothaman S, Ounsdon J. Risperidone/paKperidone induced neutropenia and lymphopenia. Aust N Z J Psychiatry 2013 47(3) 291-2. 

Only a few studies have investigated the impact of chronic Cd exposure on immunity and hemostasis. Chronic exposure of mice to Cd by ingestiOTi or inhalation inhibited cell-mediated immunity [403] and induced lymphopenia [404], but not in humans [405] or mrmkeys [406]. In contrast, in vitro studies with human peripheral blood mononuclear cells demonstrated Cd-induced interleukin-8 production with a concomitant generatirm of superoxide radicals [407]. Exposure of rats to Cd also increased platelet aggregation [408]. Moreover, chronic oral Cd... 

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