Immunomodulatory drug

Novel therapeutic immunomodulatory drugs, nutraceuticals, functional foods, and technological advances... 

Adjunctive immunomodulatory drugs such as drotrecogin-alfa can also be considered for patients with severe sepsis. 

Crane E, List A Immunomodulatory drugs. Cancer Invest 2005 23 625. [PMID 16305990]... 

Raje N, Anderson KC. Thalidomide and immunomodulatory drugs as cancer therapy. Curr Opin Oncol. 2002 14 635-640. 

Kirschbaum, B. J. (2000). Lefiunomide an immunomodulatory drug for the treatment of rheumatoid arthritis and... 

Dry eye treatment with topical artificial tears hot compressesAid care routines, environment modification, immunomodulatory drugs and nutritional supplements. (Note that estrogen or androgen-based drops may be a promising new treatment.)... 

Cytokines themselves may also be used for MS therapy. IFN-p has been in clinical use as an immunomodulatory drug for the d eatment of MS for more than 10 years. Adminisda-don of IFN-p decreases the relapse rates and new MRI lesions in padents with relapsing/remitdng MS (The IFN-p Muldple Sclerosis Study Group, 1993) or delay cUsease progression in padents with secondary progressive MS (lacobs et al., 1996 ... 

Glatiramer acetate is an immunomodulatory drug that is FDA approved and clinically indicated for... 

It has been postulated that early treatment with very high doses of intravenous A-acetylcysteine and the use of immunomodulatory drugs, such as antithymocyte globulin and ciclosporin, can improve the recovery of hematological parameters, even in the case of pancytopenia (37). One case of gold-induced aplastic anemia, unresponsive to various treatments, recovered after therapy with antithymocyte globulin (SED-12, 522). 

Zemann, B., Kinzel, B., Muller, M., Reuschel, R., Mechtcheriakova, D., Urtz, N., Bornancin, F., Baumruker, T., Billich, A. Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood 107 (2006) 1454-1458. 

SPL expression was seen to be downregulated in colon carcinoma (Oskouian et ah, 2006), but upregulated in ovarian cancer (Hibbs et ah, 2004) and atopic dermatitis (Seo et ah, 2006). Most importantly, SPL knockout mice feature postnatal mortality due to multiple congenital abnormalities, in particular of the vasculature (Schmahl et ah, 2007). Whether these findings would limit the usefulness of SIP lyase inhibitors as immunomodulatory drugs remains to be explored. 

Kawabata, T.T. Evans, E.W. (2012). Development of immunotoxicity testing strategies for immunomodulatory drugs. Toxicologic Pathology, 40, 288-293. 

The medicinal use is multivalent. Mainly used for the prevention and treatment of cardiovasculary and inflammatory diseases, as antidiabetic, against menorrhagia, as immunomodulatory drug, antithrombotic and antioxidants and several other internal and external complaints. 

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