Lymphocyte choriomeningitis virus

Baltimore D (1988) Gene therapy. Intracellular immunization. Nature 335 395-396 Basta S, Stoessel R, Easier M, van den Broek M, Groettrup M (2005) Cross-presentation of the long-lived lymphocytic choriomeningitis virus nucleoprotein does not require neosynthesis and is enhanced via heat shock proteins. J Immunol 175 796-805 Baum C (2007) Insertional mutagenesis in gene therapy and stem cell biology. Curr Opin Hematol 14 337-342... 

Material Safety Data Sheet-Infectious Substances Lymphocytic Choriomeningitis Virus. May 15,... 

Byrne, J.A. and Oldstone, M.B., Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus clearance of virus in vivo, /. Virol., 51, 682-686,1984. 

Mouse Groups of 50 male and 50 female B6C3Fi mice, eight weeks of age, were administered skin applications of 0, 88 or 177 mg/kg bw 2,3-dibromo-l-propanol (98% pure) in 95% ethanol on five days per week for 36-39 weeks (males) or 39-42 weeks (females). The study was terminated at 36-39 weeks (males) and 39 2 weeks (females) because sera from sentinel mice housed in the same room as the study animals were found to be positive for antibodies to lymphocytic choriomeningitis virus. As shown in Table 1, increased incidences of skin papillomas, forestomach papillomas and forestomach carcinomas were observed in both sexes. Hepatocellular adenomas were seen in 1/50 control, 2/50 low-dose and 9/50 high-dose p < 0.05) male mice no data for liver were reported in females (Eustis et al., 1995). 

Lymphocytic choriomeningitis virus Reovirus type 3 Sendai virus Ectromelia virus K virus... 

The primacy of 04" T lymphocytes in controlling and clearing viral infections is evident in diverse viral infections. Lymphocytic choriomeningitis virus (LCMV)-specific CD4 T lymphocytes are generated in LCMV infection, and more than 10% of this population secrete IFN-y in response to class Il-restricted LCMV peptides (Muller et al. 1992 Varga and Welsh 1998). Control of hepatitis C... 

Sinkovics J, Molnar E. Specific paralysis of antibody production in mice irrfected with lymphocytic choriomeningitis virus (in Hungarian). Kiserietes Orvostudomany Exp Med Sci. 1955 6 647-53. 

Saron MF, Fayolle C, Sebo P et al. Anti-viral protection conferred by recombinant adenylate cyclase toxins from bordetella pertussis carrying a CD8+ T-cell epitope from lymphocytic choriomeningitis virus. Proc Natl Acad Sci USA 1997 94(7) 3314-3319. 

Lymphocytic choriomeningitis virus (LCM) (neurotropic strains) ill. Bunyaviruses... 

Arenavirus (Lassa fever virus, lymphocytic choriomeningitis virus, Machupo virus, and Junin virus). Enveloped, helical, ambisense, and ssRNA (two segments). Synthesis occurs in the host cell cytoplasm maturation involves budding from the host cell plasma membrane. Virions contain ribosomes. The human pathogens Lassa, Machuppo, and Junin viruses are Biosafety Level 4 pathogens - they must be handled in the laboratory under maximum containment conditions. 

Asensio, V. C., Kincaid, C., and Campbell, I. L. (1999). Chemokines and the inflammatory response to viral infection in the central nervous system with a focus on lymphocytic choriomeningitis virus. J. Neurovirol. 5, 65-75. 

Arenavirus (Lassa fever virus, lymphocytic choriomeningitis virus, Machupo virus, Junin virus)... 

Persistent Infection of Mice with the Lymphocytic Choriomeningitis Virus... 

Shah WA, Peng H, Carbonetto S. Role of non-raft cholesterol in lymphocytic choriomeningitis virus infection via alpha-dystroglycan. J Gen Virol. 2006 87(Pt 3) 673-678. 

---