Lymphoblast receptors

McGillis, X, et al. (1987). Immunoaffinity Purification of Membrane Constituents of the IM-9 Lymphoblast Receptor for Substance P, Anal. Biochem. 164 502-513. 

Wood, C.L., and O Dorisio, M.S. (1985) Covalent cross-linking of vasoactive intestinal polypeptide to its receptors on intact human lymphoblasts./. Biol. Chem. 260, 1243-1247. 

The experiment in Figure 13-3 illustrates the use of flow cytometry to determine Kj and B ax values for binding of the es nucleoside transporter ligand, SAENTA-fiuorescein, at sites in human CEM leukemic lymphoblasts. The es nucleoside transporter is widely expressed in mammalian cells, and is concentrated in regions in the CNS that coordinately express adenosine Ai receptors (Jennings et al., 2001). 

Nakao, M. Janssen, J. W. Flohr, T. Bartram, C. R. Rapid and reliable quantification of minimal residual disease in acute lymphoblastic leukemia using rearranged immunoglobulin and T-cell receptor loci by LightCycler technology. Cancer Res. 2000, 60(12), 3281-3289. 

In a study on the immunotoxic effects of cigarette tar components, hydroquinone, at a concentration that did not affect the viability of the cells (50 pmol/L), decreased IL-2-dependent DNA synthesis and cell proliferation by > 90% in cultured human T lymphoblasts (Li et al., 1997). Hydroquinone inhibited Fc-receptor-mediated phagocytosis in mouse peritoneal macrophages only at rather high concentrations (100 pmol/L) (Manning et al., 1994). 

M24. Mirro, J., Jr., Kitchingman, G., Behm, F. G., Murphy, S. B., and Goorha, R. M., T cell differentiation stages identified by molecular and immunologic analysis of the T cell receptor complex in childhood lymphoblastic leukemia. Blood 69,908-912 (1987). 

V4. van Dongen, J. J., Quertermous, T., Bartram, C. R., Gold, D. P., Wolvers-Tettero, I. L., Comans-Bitter, W. M., Hooijkaas, H., Adriaansen, H. J., de Klein, A., Raghavachar, A., et al. T cell receptor-CD3 complex during early T cell differentiation. Analysis of immature T cell acute lymphoblastic leukemias (T-ALL) at DNA, RNA, and cell membrane level. J. Immunol. 138, 1260-1269 (1987). 

Another event causing overexpression of transcription factors is juxtaposition of these genes to a gene locus for antigen receptors in T lymphocytes. Nearly half of the genes that are translocated to antigen receptor loci in human leukaemia cells, notably in T-cell acute lymphoblastic leukaemia (T-ALL), encode helix-loop-helix (HLH) transcription factors (such as Max and MAD) (see Chapter 10 and 17). 

Travers JB, Li Q, Spredier H, Fentd RH. Binding of csabamyl PAF to Raji lymphoblast PAF receptor, bit J bnmunophatmaool 1992 14 5IS-S23... 

Although G-CSF is not believed to stimulate malignant lymphoid cells, G-CSF receptors have been found in patients with T cell leukemia, and this was associated with a significant increase in T cell leukemia cells in several patients (SEDA-21, 379). Other uncommon consequences of G-CSF have included blast mobilization with a phenotype change from common acute lymphoblastic leukemia to biphenotypic leukemia in one patient (87). 

Elass, A., Vergoten, G., Legrand, D., Mazurier, J., Elassrochard, E. and Spik, G. (1996a). Processes Underlying Interactions of Human Lactoferrin with the Jurkat Human Lymphoblastic T-Cell Line Receptor. 1. Quantitative Structure-Affinity Relationships Studies. QuantStruct.-AciRelat., 15, 94-101. 

Nk receptors have been demonstrated on human and murine T and B lymphocytes, on human IM-9 cells (lymphoblasts), on human peripheral blood monocytes, and on guinea-pig peritoneal and alveolar macrophages but not on human alveolar macrophages (Payan etal., 1983 Hartung and Toyka, 1983 Hartung etal., 1986 Lotz et al., 1988 Pujol et al., 1989 Muscettola and Grasso,... 

ZML, Chronic myelogenous leukemia ALL, acute lymphoblastic leukemia AML, acute myelogenous leukemia p210 and pl90, chimeric proteins (see text) MB (with L3, M3, M4EO, etc), French-American-British classifications TRD , T-ceU receptor P and 5 lod. Estimated frequency per clinical disease category. ... 

McKallip RJ, Lombard C, Fisher M, Martin BR, Ryu S, Grant S, Nagarkatti PS, Nagarkatti M (2002a) Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 100 627-634... 

Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase active during the process of immunoglobulin and T-cell receptor gene rearrangement early in a precursor B or T cell s life. Only normal early B and T lymphoblasts mark for TdT. The staining pattern is nuclear. TdT is a sensitive and specific antibody for lymphoblastic lymphoma/leukemia because only a small proportion of myeloid leukemia cases are positive (Fig. 6.13). 

---