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Lymphatic uptake

Jackson, A. J. (1981). Intramuscular absorption and regional lymphatic uptake of liposome-entrapped inulin. Drug Metab. Dispos., 9, 535-540. [Pg.323]

Parker, R. J., Priester, E. R., and Sieber, S. M. (1982). Comparison of lymphatic uptake metabolism, excretion, and biodistribution of free and liposome-entrapped (l cjcytosine beta-D-arabinofuranoside following intraperitoneal administration in rats, Drug. Me tab. Dispos., 10, 40-46. [Pg.331]

The absorption of drugs from the rectal [32] cavity has been studied in some detail. Muranishi et al. [34] have shown that a significant increase in the absorption and lymphatic uptake of soluble and colloidal macromolecules can be achieved by pretreating the rectal mucosal membrane with lipid-nonionic surfactant mixed micelles. They found no evidence of serious damage of the mucosal membrane. Davis [30] suggested that the vaginal cavity could be an effective delivery site for certain pharmaceuticals, such as calcitonin, used for the treatment of postmenopausal osteoporosis. [Pg.538]

There are fewer reports on other parenteral routes of administration of emulsions such as intramuscular, subcutaneous, and intraperitoneal. V Mer-in-oil and w/o/w emulsions of bleomycin, mytomycin C, and 5-Luorouracil have been administered by these routes, apparently resulting in increased regional lymphatic uptake, hence the term lymphotropic emulsions (Davis et al., 1987). Gasco et al. (1990) developed a w/o emulsion of an LHRH analog measurements of testosterone levels after intramuscular administration to rats suggested that the formulation led to prolonged release of the drug. [Pg.211]

Hauss, D.J., H.Y. Ando, D.M. Grasela, and E.T. Sugita. 1991. The relationship of salicylate lipophilicity to rectal insulin absorption enhancement and relative lymphatic uptake. J Pharma-cobiodyn 14 139. [Pg.29]

Nishihata, T., et al. 1984. Effect of adjuvants on the rectal absorption and lymphatic uptake of pepleomycin in rats. J Pharmacobiodyn 7 278. [Pg.172]

A variety of diseases affect the lymphatic system early in their time course. For example, many cancers spread by lymphatic dissemination, and HIV, fungal, and bacterial infections are located primarily in the lymph nodes. The high prevalence of lymph node involvement in disease is due to the role of lymphatic tissue in the provision of the body s immune response. Intralymphatic and interstitial administration are two efficient access routes. However, the oral route may also prove to be important for the lymphatic uptake of lipophilic drags and macromolecules. [Pg.165]

Alterations in the capillary filtration of macromolecules are well documented in diabetic patients and experimental diabetes. Various flavonoids, including anthocyanins and ginkgo biloba extracts, have been shown to be effective against experimentally induced capillary hyperfiltration. Cohen-Boulakia et al." demonstrated that anthocyanins were effective in preventing the increase in capillary filtration of albumin and the failure of lymphatic uptake of interstitial albumin in male rats with streptozotocin-induced diabetes. In an earlier study, Valensi and coworkers demonstrated in a placebo-controlled trial that a purified micronized flavonoid fraction (Daflon 500 mg) can improve and even normalize capillary filtration of albumin in diabetic patients. [Pg.13]

Caldwell, L. Nishihata, T. Rytting, J. Higuchi, T. Lymphatic uptake of water-soluble drugs after rectal administration. J. Pharm. Pharmacol 1982, 34, 520-522. [Pg.1309]

Intraperitoneal or intramuscular delivery of particulates is known to result in lymphatic uptake, and may be a means of targeting lymph nodes local to the injection site in a more efficient manner than intravenous administration. ... [Pg.2570]

The use of the lauric acid salt of propranolol for extended release also resulted in increased bioavailability possibly linked to micellar solubilization, ion pair formation, and preferential lymphatic uptake. [Pg.3182]

Macromolecular salts, using as counterions polyacrylic acids, sulfonic, or phosporylated polysaccharides, have been used to alter drug distribution, for example, by promoting lymphatic uptake of anti-biotics.f ... [Pg.3182]

Oussoren C, Zuidema J, Crommehn DJA, et al. Lymphatic uptake and biodistribution of liposomes after subcutaneous injection. II. Influence of liposomal size, lipid composition and lipid dose. Biochim Biophys Acta 1997 1328 261-272. [Pg.384]

The use of local anesthetic agents or hyaluronidase prior to administering the labeled preparation have been shown to negatively affect lymphatic uptake. [Pg.227]

Single-pass intestinal perfusion studies For evaluatton of intestinal prermeability and lymphatic uptake Predict the exact mechanism of absorption, that is, passive absorption, carrier mediated absorption or active transport Evaluate the P-gp efflux and role of transporters (MRP, BCRP2) in reducing the oral bioavailability of drugs... [Pg.109]


See other pages where Lymphatic uptake is mentioned: [Pg.305]    [Pg.320]    [Pg.537]    [Pg.541]    [Pg.244]    [Pg.169]    [Pg.134]    [Pg.165]    [Pg.18]    [Pg.2732]    [Pg.4127]    [Pg.337]    [Pg.337]    [Pg.340]    [Pg.1003]    [Pg.127]    [Pg.233]    [Pg.642]    [Pg.223]    [Pg.802]    [Pg.340]    [Pg.341]    [Pg.345]    [Pg.345]    [Pg.352]    [Pg.461]    [Pg.210]    [Pg.340]    [Pg.341]   
See also in sourсe #XX -- [ Pg.251 , Pg.279 ]




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