Lymphadenopathy associated

Muesing MA, Smith DH, Capon DJ (1987) Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein. CeU 48(4) 691-701 Nicholson JK, Cross GD, CaUaway CS, McDougal JS (1986) In vitro infection of human monocytes with human T lymphotropic virus type Ill/lymphadenopathy-associated virus (HTLV-III/ LAV). J Immunol 137(l) 323-329... 

The human immunodeficiency virus (HIV lymphadenopathy-associated virus, LAV human T-cell lymphotrophic virus type 3, HTLV III) is responsible for acquired immune deficiency syndrome (AIDS see Chapter 3). Because of the hazard and difficulties of growing the virus outside humans, a different approach has to be examined for determining viral sensitivity to disinfectants. 

Cellulitis is characterized by erythema and edema of the skin. The lesion, which may be extensive, is painful and nonelevated and has poorly defined margins. Tender lymphadenopathy associated with lymphatic involvement is common. Malaise, fever, and chills are also commonly present. There is usually a history of an antecedent wound from minor trauma, an ulcer, or surgery. 

Martin, L.S., J.S. McDougal, and S.L. Loskoski. 1985. Disinfection and inactivation of the human T lymphotropic virus type III/lymphadenopathy-associated virus. J Infect Dis 152 400. 

In 1983, human immunodeficiency virus (HIV) was isolated from a patient with lymphadeno-pathy, and by 1984 it was demonstrated clearly to be the causative agent of AIDS. The virus, which belongs to the lentivirus subfamily of the large family of retroviruses (Retroviridae), was formerly called lymphadenopathy associated virus (LAV), human T-lymphotropic virus (HTLV) type III, and AIDS-associated retrovirus (ARV). 

Centers for Disease Control (CDC). Recommendations for preventing transmission of infection with human T-lymphotropic virus type Ill/lymphadenopathy-associated virus in the workplace. MMWR Morb Mortal Wkly Rep 1985 34(45) 681-6,691-5. 

Mitsuya, H., Weinhold, K. J., Rurman, R. A., St. Clair, M. H., Lehrman, S. N., Gallo, R. C., Bolognesi, D., Barry, D. W. S. Broder 3 -Azido-3 -deoxythymidine (BW A509U) An antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type Ill/lymphadenopathy associated vims in vitro, Proc. Natl. Acad. Sci. 1985, 82, 7096-7100. 

Tender lymphadenopathy associated with lymphatic involvement is common. 

Sarin, P.S. Sun, D. Thornton, A. Muller, W.E.G. Inhibition of the Replication of Etiologic Agent of Acquired Immune Deficiency Syndrome (Human T-Lymphotropic Retrovirus /Lymphadenopathy-Associated Virus) by Avarol and Avarone. J. Natl. Cancer Inst. 1987, 78, 663-666. 

Mitsuya H, Broder S (1986) Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type Ill/lymphadenopathy-associated virus (HTLV-III/LAV) by 2, 3 -dideoxynucleosides. Proc Natl Acad Sci USA 83 1911-1915 Miyako K, Kai Y, Me T, Takeshige K, Kang D (1997) The content of intracellular mitochondrial DNA is decreased by l-methyl-4-phenylpyridium ion (MPP ). J Biol Chem 272 9605-9608... 

Montagnier, L. (1986) Lymphadenopathy associated virus its role in the pathogenesis of AIDS and related diseases. Prog. Allergy 37,46-64. 

Balzarini, J. Mitsuya, H. De Clercq, E. Broder, S. Aurintricarboxyhc acid and Evans Blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type 111/lymphadenopathy-associated virus. Biochem. Biophys. Res. Commun. 1986,136, 64-71. 

Ziza J, Bmn-Vezinet E, Venet A, et al. Lymphadenopathy-associated vims isolated from bronchoalveolar lavage fluid in AlDS-related complex with lymphoid interstitial pneumonitis (letter). N Engl J Med 1985 313 183. 

Crestani B, Monnier A, Kambouchner M, et al. Tracheobronchial amyloidosis with hilar lymphadenopathy associated with a serum monoclonal immunoglobuhn. Eur Respir J 1993 6(10) 1569-1571. 

Klatzmann, D., F. Barre-Sinoussi, M.T. Nu-geyre, C. Dauget, E. Vilmer, C. Griscelli, F. Brun-Vezinet, C. Rouzioux, J.C. Gluckman, J-C. Chermann, and L. Montagnier. 1984. Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes. Science 225 59-63. 

The significance of these results is difficult to assess as it is based on small numbers. As with other studies 12 ) which came to the same conclusion, this was a retrospective analysis. Long-term DPH therapy (range of 7—23 years) resulted in malignant lymphoma in 4 cases, in one of whom there was preceding leukopenia and in another thrombocytopenia 2 patients were successfully treated with chemo- or radiotherapy (19 ). DPH therapy may also result in unifocal lymphadenopathy associated with marked tenderness (5 ). 

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