Lung dosimetry models

Martell, E.A., Critique of Current Lung Dosimetry Models for Radon Progeny Exposure, this volume (1987). 

Critique of Current Lung Dosimetry Models for Radon Progeny Exposure... 

Current lung dosimetry models are based on the assumption that basal cells of the bronchial epithelium are the critical target cells for malignant transformation and that the alpha dose to these cells is the relevant radiation dose. 

The most significant information given in Table I is that the radon daughter ions do contribute to the total internal dose if only at about 3% in this study. The effect of free ions in contrast with daughters attached to aerosols is substantial when the mechanics of deposition in the bronchial tree and lungs are taken into account. The dose from "unattached" Po-218, which includes the Po-218 positive ions as a major component, can be from 3 to 40 times that of the attached Po-218 (NCRP, 1984). Current dosimetry models allow for the important role played by Po-218 in small-ion form. Hence, their effect is significantly greater than the 3% contribution to the PAEC (WL) shown in Table I. 

Hofmann,W., and F. Daschil, The Relevance of Animal Models for Radionuclide Inhalation in Man, in Current Concepts in Lung Dosimetry, Proc. of the 30th Annual Meeting of the Radiation Research Society at Salt Lake City 1982 (D.R. Fisher, ed) pp 95-102, Utah... 

Kuempel ED, Tran CL, Castranova V, Bailer AJ (2006). Lung dosimetry and risk assessment of nanoparticles evaluating and extending current models in rats and humans. Inhal. Toxicol. 18 717-24. 

James A, Roy M. 1987. Dosimetric lung models. In Gerber G, et al., ed. Age-related factors in radionuclide metabolism and dosimetry. Boston Martinus Nijhofif Publishers, 95-108. 

Dosimetry. Dosimetry for inhaled Rn-d particles has made significant advances over the past twenty years. Lung modelling, based initially to a large extent on the WEIBEL A -symmetrical lung model, has been... 

Task Group on Lung Dynamics. (1966). Deposition and retention models for internal dosimetry of the human respiratory tract. Health Phys. 12 173-207. 

Task Group on Lung Dynamics, Deposition and Retention Models for Internal Dosimetry of the Human Respiratory Tract, Health Physics. 1966, 12., 173-207. 

SC 46-10 Assessment of Occupational Doses from Internal Emitters SC 46-11 Radiation Protection During Special Medical Procedures SC 46-13 Design of Facilities for Medical Radiation Therapy SC 57 Dosimetry and Metabolism of Radionuclides SC 57-2 Respiratory Tract Model SC 57-9 Lung Cancer Risk SC 57-10 Liver Cancer Risk SC 57-14 Placental Transfer SC 57-15 Uremium... 

Egan, M.J. Nixon, W. (1985) A model of aerosol deposition in the lung for use in inhalation dose assessments. Radiation Protection Dosimetry, 11, 5-17. 

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