Dosimetry internal

Silk TJ, Phipps AW, Bailey MR. 1997. Effects on dose coefficients for workers of recent changes in internal dosimetry. Radiat Prot Dosim 71(1) 7-21. 

Absorbed Fraction—A term used in internal dosimetry. It is that fraction of the photon energy (emitted within a specified volume of material) which is absorbed by the volume. The absorbed fraction depends on the source distribution, the photon energy, and the size, shape and composition of the volume. 

Cifffoy P, Tanaka T, Johansson E, Brochot C (2011) Linking fate model in freshwater and PBPK model to assess human internal dosimetry of B(a)P associated with drinking water. Environ Geochem Health 33 371-387... 

Jacobi, W., and K. Eisfeld, Internal Dosimetry of Radon-222, Radon-220 and their short-lived daughters, in Proc. Nat. Rad. Env., Bombay, (1981), 131-143, (Vohra, Mishra, Pillai, and Sadasivan (eds)), Wiley East, Ltd, (1982). 

ICRP (1966). International Commission on Radiological Protection, Deposition and retention models for internal dosimetry of the human respiratory tract, Health Phys. 12,173. 

Dosimetry models are used to estimate the internally deposited dose from exposure to radioactive substances. The models for internal dosimetry consider the quantity of radionuclides entering the... 

Kilbum KH, Warshaw R, Boylen CT, et al. 1990. Cross-shift and chronic effects of stainless-steel welding related to internal dosimetry of chromium and nickel. Am J Ind Med 17 607-615. 

Task Group on Lung Dynamics, Deposition and Retention Models for Internal Dosimetry of the Human Respiratory Tract, Health Physics. 1966, 12., 173-207. 

The dose estimate D in each organ is made by using the following internal dosimetry equation ... 

Interest in particle deposition after World War II was fuelled by concern about possible deposition of radioactive particles. In 1965, The International Radiological Protection Commission (IRPC) Task Force on Lung Dynamics submitted its report Deposition and retention models for internal dosimetry of the human respiratory tract (Task Group on Lung Dynamics, 1966). The Task Force, comprising Bates, Fish, Hatch, Mercer and Morrow, undertook a detailed examination of the area and developed a deposition model using methods of calculation similar to those used... 

Figure 12. Two ventilatory states, i.e. 750 ml and 2150 ml tidal volume ( 11 and 32 1 min volumes, respectively), are used to indicate the order and direction of change in compartmental deposition which are induced by such physiological factors. Note the crossover in the P curves at approximately 0.8 pm diameter (AMAD). Reproduced with permission from Task Group on Lung Dynamics (1966). Deposition and retention models for internal dosimetry of the human respiratory tract. Health Physics, 12, 173-207. Lippincott, Williams Wilkins...

Bates, D.V., B. R. Fish, T. F. Hatch, T. T. Mercer, and P. E. Morrow. 1966. Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics. Health Phys. 12 173-207. 

For each approved radiopharmaceutical, the SPC states relevant information concerning pharmaceutical form, approved clinical indications, posology, internal dosimetry and the effective radiation dose resulting from approved diagnostic procedures, detailed instructions for kit labeling, a method to verify the radiochemical purity after labeling before administration, the shelf-life, etc. 

The internal dosimetry program generally relies on in vitro (outside) or in vivo (inside) monitoring capabilities. In vitro programs use an external radiation... 

Pilot human dosimetry studies have demonstrated the usefulness of adduct measurements in exposure assessments. Higher adduct levels in heavily exposed coke oven workers compared to those with lower exposures or controls have been reported using USERIA (3 )> ELISA (36) or the P-post1abe1ing assay (41). Tobacco consumption is also positively correlated with adduct formation (49). Chemotherapeutic trials are among the best evidence that adduct levels are related to exposure because in these cases, negative controls are truly negative. The development of immunoassays for cisplatin-DNA adducts by Poirier et a1., have led to internal dosimetry estimates and predictions for prognosis (35). Levels of aflatoxin B -adducts have also been identified in human liver and breast with ELISA (40.871. in serum albumin with RIA (88) and ELISA (38)- Multiple adduct assessments are also feasible (Table III) (89). 

Makrigiorgos GM, Adelstein SJ, Kassis Al. Limitations of conventional internal dosimetry at the cellular level. J Nucl Med 1989 30 1856-1864. 

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