Lung cancer genetic factors

The majority of people who smoke never develop lung cancer. Genetic risk factors may predispose certain smokers to lung cancer. After adjustments for age, smoke exposure, occupation, and gender, relatives of a lung cancer patient have approximately a twofold risk of developing lung cancer. The... 

Cigarette smoking is responsible for about 80% of lung cancer cases. Other risk factors include exposure to respiratory carcinogens (e.g., asbestos, benzene), genetic risk factors, and history of other lung diseases (e.g., tuberculosis, pulmonary fibrosis). 

Gurubhagavatula S, Liu G, Park S et al. XPD and XRCCl genetic polymorphisms are prognostic factors in advanced non-small-cell lung cancer patients treated with platinum chemotherapy. J Clin Oncol 2004 22 2594-2601. 

Cadranel J et al (2011) Genetic profiling and epidermal growth factor receptor-directed therapy in nonsmall cell lung cancer. Eur Respir J 37 183-193... 

Rittmeyer L, Yang P, Schwartz AG, et al. 1995. Genetic and environmental factors in lung cancer susceptibility [Abstract]. Am J Hum Genet 57 A76. 

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