Lung cancer environmental factors

Wicken, A.J., and S.F.Buck 1964. Report on a Study of Environmental Factors Associated with Lung Cancer and Bronchitis Mortality in Areas of North East England. Research Paper No. 8. Tobacco Research Council, London. 

Rittmeyer L, Yang P, Schwartz AG, et al. 1995. Genetic and environmental factors in lung cancer susceptibility [Abstract]. Am J Hum Genet 57 A76. 

Besides inherent differences from one cell type to another, environmental factors are likely to contribute to the variable frequency of p53 mutations found in human cancers. The vast majority of head and neck cancers and lung cancers of smokers harbor a p53 mutation, whereas in cancers of non-smokers the mutation frequency is around 20% (Brennan et al., 1995 Hernandez-Boussard and Hainaut, 1998 Kondo et al., 1996 Montesano et al.,... 

According to recent epidemiological studies, the majority of cancer cases derive from environmental causes, whose factors are attributed to either the indoor environment or outdoor air pollution and soil contamination (Doll and Peto 1981). In deed, the relative risk of lung cancer mortality increases by some 8—27% in heavily polluted areas (Beeson et al. 1998). Ghazaouet city homes the complex of non-ferrous metals (En-Metanof) which uses the pyrometallurgical process. It uses 100000-115000 t/year of raw material for polymetallic sulphide (El Abed blend), and produces 30000-40000 t/year of Zn, 100-150 t/year of Cd and 50000-80000 t/year of H2SO4. 

In the epidemiological literature related to cancer,one finds a continuing debate about the influence on cancer mortality rates, particularly on lung cancer of what has been termed the "urban factor" that is a sum of socio-economic conditions and environmental agents, present in urban but not in rural areas. (7, 4, 1, 40, 29,46, 41, 37, 39, 15). Nevertheless, up to now, there is no agreement as to the existence of a real excess of lung cancer mortality in... 

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