Low receptor

Low Receptor Hoods Low receptor hoods are much easier to design, since entrainment of air into the plume and the effects of turbulent cross-drafts are not significant problems. In this case, the diameter of the plume at the hood face, dp, is assumed to equal the diameter of the source, d,.. Accord-... 

The maximal response in the presence of antagonist is given by (1 + x)/(l + z + [B]/Kb). It can be seen that for low values of z (low efficacy agonist and/or low receptor density or poor receptor coupling) the maximal response to the agonist will be <1. 

The diverse effects of somatostatin, such as inhibition of cell proliferation and hormone release, led to the suggestion that it could be used for the treatment of various diseases. However, its short plasma half-life (less than 3 min) and its relative low receptor subtype... 

STD NMR is based on the accumulation of saturated ligands in solution. Hence, working with very low receptor quantities is one of the great benefits of this technique. Therefore, especially for systems where the amount of material is a limiting factor, such as viruses or VLPs, these experiments will be very helpful. 

Seeman P, Tallerico T (1999) Rapid release of antipsychotic drugs from dopamine d2 receptors An explanation for low receptor occupancy and early clinical relapse upon withdrawal of clozapine or quetiapine. Am J Psychiatry 156(6) 876-884... 

Equation 7.10 predicts that in systems of low receptor density and/or efficiency of coupling (or for agonists of low intrinsic efficacy), conditions whereby no shift of the... 

An illustrative example of differential zonal distribution in closely related species was provided by Insel et al. (1994), who studied the distribution of vasopressin V,a receptors in the brain of different species of voles (microtine rodents). A complex distribution with alternating bands of high and low receptor density was observed in... 

Clonal indifference (ignorance). Failure of B or T cells expressing anti-self-receptors to interact with antigen (e.g. by low valency, low concentration, or sequestration of antigens low receptor avidity lack of costimulatory molecules). Primary mechanism involved in the induction and maintenance of selftolerance. 

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