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LNCaP cells, arrest

In in vitro studies, using PCa LNCaP and PC-3 cells, Ivanov et al. [190] reported that treatment of cells with lycopene-based agents (100 nM) resulted in mitotic arrest, with cells accumulating in GO/Gl phase. There was block in Gl/S transition mediated by decreased levels of cyclins Dl, E, cdk-4, and suppression of retinoblastoma phosphorylation. These responses correlated with decreased IGFIR expression and activation, increased IGFBP-2 expression, and decreased AKT activation. Exposure to lycopene also induced a profound apoptotic response in LNCaP cells. [Pg.3900]

Hwang, E. S. and P. E. Bowen. 2004. Cell cycle arrest and induction of apoptosis by lycopene in LNCaP human prostate cancer cells. J Med Food 7(3) 284-289. [Pg.431]

Hwang, E-S and PE Bowen. 2005b. Effects of tomato paste extracts on cell proliferation, cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells. Biofactors 23 75-84. [Pg.461]

In a recent study, LNCaP and PC3 prostate cancer cells treated with lycopene-based agents have been reported to undergo mitotic arrest. Lycopene s antiproliferative effects were likely achieved through a block in Gl/S transition mediated by decreased levels of cyclins D1 and E and cyclin-dependent kinase4 and suppressed retinoblastoma phosphorylation (Ivanov et al., 2007). [Pg.473]

Treatment of endometrial cancer (EC) cells with clotrimazole and TRAM-34, two agents known to inhibit SK4 channels, suppressed the proliferation of EC cells and arrest the EC cell cycle at the G0/G1 phase. Similarly, downregulation of SK4 by siRNA inhibited EC cell proliferation and arrested its cell cycle at the G0/G1 phase (Wang et al. 2007). Moreover, clotrimazole also inhibits proliferation of human prostate cancer cell lines, such as LNCaP and PC-3 cells (Parihar et al. 2003). [Pg.62]

Induction of cell cycle arrest and apoptosis by neochamaejasmin A in human prostate LNCaP cancer cells. [Pg.139]

B1 and Bcl-XL, and induction of caspase-3 protein syntheses in an AR- and p53independent manner, resulting in cell growth arrest at the G2/M phase (or at the G1 phase at lower concentrations) or apoptosis [48-55]. In both LNCaP and PC3 cells. [Pg.71]

Sulforaphane has been shown to induce both apoptosis and cell cycle arrest in several cell lines, including HT29 human colon cancer cells [56], LNCaP human prostate cancer cells [57], and Jurkat human T-leukemia cells [58]. Incubation of such cells with 3-30 pM SF for 24-48 hours resulted in a dose-dependent induction of apoptosis and cell cycle arrest, showing that this compound can induce apoptosis and arrest cell growth and suggesting that this activity is unlikely to be cell type specific. There is also evidence that the concentration of SF required to induce apoptosis and cell cycle arrest may be much... [Pg.120]

Noscapine- derivative EMOll A /ni dissipation, increase of PUMA, BAX, caspase-3 activation, cleavage PARP, arrest G2/M phase, activation of the mitotic checkpoint. Human prostate cancer cell lines PC-3, LNCaP, C4-2andC4-2B. Brominated analog of the plant-derived alkaloid noscapine. [145]... [Pg.13]


See other pages where LNCaP cells, arrest is mentioned: [Pg.428]    [Pg.172]    [Pg.176]    [Pg.315]    [Pg.118]    [Pg.177]    [Pg.229]    [Pg.121]    [Pg.482]    [Pg.106]    [Pg.1875]    [Pg.505]    [Pg.135]    [Pg.445]    [Pg.476]    [Pg.117]    [Pg.198]    [Pg.440]    [Pg.71]    [Pg.702]    [Pg.84]    [Pg.84]    [Pg.93]    [Pg.199]    [Pg.228]    [Pg.211]    [Pg.8]    [Pg.50]    [Pg.437]    [Pg.570]    [Pg.728]   
See also in sourсe #XX -- [ Pg.176 ]




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