Liver tests

This gene is broadly distributed in skeletal muscle, heart, uterus, and in a variety of non-muscle cells. The mRNA levels are particularly high in intestine, lung and spleen, whereas they are very low in liver, testes, kidney and pancreas. In the muscle tissue SERCA3 may be confined primarily to non-muscle cells (vascular smooth muscle, endothelial cells, etc.). The C-terminus of SERCA3 is Asp-Gly-Lys Lys-Asp-Leu-Lys (Table I) it may serve as a sorting signal for retention of the enzyme in the endoplasmic reticulum [57]. 

Ursodiol may slow progression of liver disease. It improves bile flow and may displace toxic bile acids that accumulate in a cholestatic liver, stimulate bicarbonate secretion into the bile, offer a cytoprotective effect, and reduce elevated liver tests. Ursodiol is typically dosed at 15 to 20 mg/kg per day in two divided doses and may be rounded to the nearest tablet size.5,7... 

Filipy RE, Kathren RL, Mclnroy JF. 1992. Relative concentrations of plutonium and americium in the liver, testes, and thyroid gland. Health Phys 62(6)(Suppl.) S17. 

Liver tests less than 2-3 times upper limit of normal... 

SC-38394 None Liver, testes, bone marrow, thymus, kidney... 

Rare instances of severe liver injury, including hepatic necrosis, have been reported. Carefully evaluate patients in whom an abnormal liver test has occurred, or who have signs or symptoms suggesting liver dysfunction. 

Hepatic function impairment Only give patients with abnormal liver tests or liver disease rifapentine in cases of necessity and then with caution and under strict medical supervision. In these patients, carefully monitor liver tests (especially serum transaminases) prior to therapy and then every 2 to 4 weeks during therapy. If signs of liver disease occur or worsen, discontinue rifapentine. 

Liver dysfunction and peliosis hepatis are occasional complications of tamoxifen. There have also been reports of cirrhosis with fatty liver in women taking tamoxifen after surgery for breast cancer (55). The condition is reversible, and liver tests are advisable so that the tamoxifen can be promptly withdrawn if necessary. 

One liver sample from 252 samples of poultry liver that were tested was found to contain residues of monensin (5 pg/kg). Three samples from 237 samples of poultry (broiler) liver tested for the presence of this compound contained lasalocid at concentrations of 140 pg/kg, 63 pg/kg and 62 /xg/kg. In both cases (monensin and lasalocid) the problem appeared to be caused by feed manufacturing, transport and storage procedures. 

Subcutaneous injection of rabbits with aluminum chloride daily for 28 days was associated with significant accumulation of aluminum in bone, followed in order by significantly increased aluminum concentrations in renal cortex, renal medulla, liver, testes, skeletal muscle, heart, brain white matter, hippocampus, and plasma (Du Val et al. 1986). Because the brain tissue of treated rabbits had the lowest aluminum concentrations of the tissues evaluated, the authors suggested that there was a partial blood-brain barrier to entry of aluminum. 

Lo Iacono O, Petta S, Venezia G, Di Marco V, Tarantino G, Barbaria F, et al. Anti-tissue transglutaminase antibodies in patients with abnormal liver tests Is it always coeliac disease Am J Gastroenterol 2005 100 2472-2477. 

Coverdale SA, Samarasinghe DA, Lin R, et al. (2003) Changes in antipyrine clearance and platelet count, but not conventional liver tests, correlate with fibrotic change in chronic hepatitis C value for predicting fibrotic progression. Am J Gastroenterol 98 1384—1390. 

In patients with seizure disorders, concomitant medical illness, and/or those with multiple concomitant long-term medications, periodic liver tests and blood counts may be prudent... 

Liver tests may be necessary during treatment in patients who develop nausea, vomiting, or anorexia... 

If pemoline therapy is discontinued and then restarted, the liver testing should be done prior to reinitiating treatment and then every 2 weeks... 

Selection criteria for liver tests 92 9.5 Caffeine elimination test (CET) 109... 

A great number of liver tests are nonspecific, and their results are pathological in other diseases as well. It is therefore necessary to consider the specificity, sensitivity and clinical validity of the respective tests when setting up the diagnostic procedure. 

In order to give due consideration to these facts and reduce the uncertainties of liver diagnostics, a large number of function tests with a multitude of modifications were developed. Flowever, the application of such batteries of tests or liver test arrays as well as shotgun investigations did not only result in unnecessary discomfort for patients and staff alike, but also in the uneconomical use of laboratory testing. Furthermore, these tests failed to improve liver diagnostics. 

Rational and reliable liver diagnostics requires the simultaneous application of certain liver tests for ascertaining important parameters of cellular integrity and essential liver functions. In some cases, they have to be complemented by further specific tests. 

Kamath, PS. Clinical approach to the patient with abnormal liver test... 

Rondana, M., Milani, L., Merkel, C., Caregaro, L., Gatta, A. Value of prealbumin plasma levels as liver test. Digestion 1987 37 72-78... 

Sorbi, D., McGill, D.B., Thistle, J.L., Therneau, T.M., Henry, J., Lindor, K.-D. An assessment of the role of hver biopsies in asymptomatic patients with chronic liver test abnormalities. Amer. J. Gastroenterol. 2000 95 3206-3210... 

Bertolotti, M., Morselli-Labate, AM., Riusticali, A.G., Loria, R, Ca-rulli, N. Ursodeoxycholic acid improves liver tests in chronic hepatitis. Results of a randomized controlled trial. Clin. Drug Invest. 1999 17 425-434... 

Bowy er, B. A., Miles, J. M ilayntond, M. W-, and Fleming, C. R. (1988), L-Carnitino therapy in home parenteral nutrition patients with abnormal liver tests and low plasma carnitine concentrations. CastToentetolcg)t 94,434-436. 

A 43-year-old man had a moderate rise in hepatic transaminase activities after 4 weeks of interferon alfa treatment. His liver tests normalized after withdrawal, but the aspartate transaminase activity increased dramatically shortly after treatment was restarted. His... 

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