Liver neoplastic disease

Adrenocortical insufficiency Organ transplants Liver disease Adrenogenital syndrome Nephrotic syndrome Acute spinal cord injury Hyp ere alemia Hematologic disorders Myasthenia gravis Neoplastic disease... 

Severe reactions Because of the possibility of severe toxic reactions (which can be fatal), fully inform patients of the risks involved and assure constant supervision. Deaths Use methotrexate only in life-threatening neoplastic diseases, or in patients with psoriasis or rheumatoid arthritis (RA) with severe, recalcitrant, disabling disease that is not adequately responsive to other forms of therapy. Deaths have occurred with the use of methotrexate in malignancy, psoriasis, and RA. Closely monitor patients for bone marrow, liver, lung, and kidney toxicities. 

The numerous causes of human zinc deficiency, and conditions in which it exists, have been summarized by Prasad.50 52 They include nutrition (inadequate diet), excessive alcohol ingestion, liver disease, gastrointestinal disorders (such as Crohn s disease), neoplastic diseases (conditioned... 

Elevation of y-GT is found in cholestasis, liver cirrhosis, viral hepatitis, fatty liver, porphyria, toxic liver damage, pancreatitis and pancreatic cancer, myocardial infarction, nephrotic syndrome, diabetes mellitus, right heart failure, obesity, nicotine abuse, and brain tumours. There is a good correlation of y-GT with CEA in colon cancer, involving a metastatic spread to the liver - an increase in y-GT in neoplastic disease is likewise supportive of the diagnosis of hepatic metastases. 

Boca, M., Hantak, L, Mickulecky, M., Ondrejka, R Biochemical pattern of the ascitic fluid in liver cirrhosis and in neoplastic diseases. Gastroenterol. Journ. 1991 51 136-137... 

Raised liver enzyme activities have been reported in most studies. In some articles this effect was described as transient, in others as disappearing after withdrawal. The incidence varies from a few percent of cases to 35 5%, but occasionally the effect has been recorded in aU cases treated. A temporal relation between these hver function changes and fluconazole treatment has been shown in many cases. Severe liver toxicity has not been reported (SED-12, 681) (21). While asymptomatic rises in transaminases were noted in some children with neoplastic disease who were treated concomitantly with fluconazole in a small study (48), there were no significant changes in a larger study in cancer patients treated with placebo or fluconazole 400 mg (42). 

Water retention due to sodium chloride (salt) is a common manifestation that leads to weight gain. Edema is also found in patients with cardiac heart failure, renal insufficiency, liver cirrhosis, and hypo-proteinemia. When large doses are used to treat neoplastic diseases, compounds with 17-alkyl substitutions can cause cholestatic hepatitis at high doses, jaundice is the most common clinical feature with accumulation of bile in the bile capillaries. Jaundice usually develops after 2-5 months of therapy. It can be detected by increases in plasma aspartate aminotransferase and alkaline phosphatase. 

Neoplastic Diseases Involving the Liver 7.8.1. Primary Hepatic Tumors... 

The array of medical and neoplastic diseases of the pancreas, extrahepatic and intrahepatic biliary tree, and liver are vast. Morphologic impressions remain the bedrock for proper interpretation of IHC and other specialized molecular anatomic tissue testing. 

This enzyme is found in various animal tissues and that from sheep liver has been purified 280-fold 11). Both cytidine and deoxycytidine are deaminated, as are the 5-halogen derivatives (e.g., 5-fluoro-deoxycytidine). Cytosine, cytidylate, and deoi i idylate are not deaminated by this enzyme. Cytosine arabinoside (iHS-D-arabinofurano lcytosine), which has an important use in the treatment of human neoplastic disease, is a substrate for cytidine deaminase in the human, this compound is rapidly deaminated to yield the inactive uracil arabinoside 12). Cytidine deaminase is very active in E. ccli and S. typhimwrium, but is absent from yeasts and lactobacilli (7). The E. coli enzyme has been partly purified IS) and has a specificity similar to that of the animal enzyme. The E. coli enzyme deaminates 5-methyldeoxycytidine, enabling this compound to support the growth of a thymine-requiring E. coli mutant 11. ... 

Canavalia ensiformis, Phaseolus vulgaris, and Triticum vulgare react with arylamidase, alkaline phosphatase, y-glutamyltransferase, and cholinesterase of human sera by formation of enzymically active complexes. Arylamidase, alkaline phosphatase, and cholinesterase react more intensely in sera of patients with liver and neoplastic diseases. 

As discussed in Section 2.6, chronic alcoholics receiving Antabuse (disulfiram) therapy are potentially more susceptible to toxic and neoplastic effects of 1,2-dibromoethane. It also follows that individuals with compromised liver or renal function or with asthma or other chronic respiratory diseases may have increased susceptibility to the toxic effects of 1,2-dibromoethane however, chemical-specific effects have not been identified. 

The cause of the pain should first be assessed. A tricyclic antidepressant is appropriate for neuropathic pain due to neoplastic extension to peripheral nerves, a corticosteroid for nerve entrapment, an opioid for a liver distended with metastatic disease, a NSAID for bony secondaries. 

Grieco, A., Castellano, R., Matera, A., Marcoccia, S., Di Rocco, P., Ragazoni, E., Vecchio, F.M., Gasbarrini, G. Antipyrine clearance in chronic and neoplastic liver diseases a study of 518 patients. J. Gastroenterol. Hepatol. 1998 13 460-466... 

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