Liquid dosage forms lotions

Lotion An emulsion, liquid dosage form. This dosage form is generally for external application to the skin. 

More elaborate sample preparation is often needed for complex sample matrices, e.g., lotions and creams. Many newer SP technologies such as solid-phase extraction (SPE), supercritical fluid extraction (SFE), pressurized fluid extraction, accelerated solvent extraction (ASE), and robotics are frequently utilized (see Ref. [2]). Dosage forms such as suppositories, lotions, or creams containing a preponderance of hydrophobic matrices might require more elaborate SP and sample cleanup, such as SPE or liquid-liquid extraction. 

The inclusion of the a routine microbial limit test in a marketed product stability protocol depends on the pharmaceutical dosage form. Typically, the test would be used only for nonsterile products, especially oral liquids, nasal sprays, and topical liquids, lotions, and creams that have sufficient water activity to support the growth of microorganisms. In contrast, tablets, powder- and liquid-filled capsules, topical ointments, vaginal and rectal suppositories, nonaqueous liquids and inhalation aerosols with a water activity too low to allow for the product to support the growth of microorganisms would not be routinely tested. 

Emulsion A dosage form consisting of a two-phase system comprised of at least two immiscible liquids, one of which is dispersed as droplets (internal or dispersed phase) within the other liquid (external or continuous phase), generally stabilized with one or more emulsifying agents. (Note Emulsion is used as a dosage form term unless a more specific term is applicable, e.g. cream, lotion, ointment.). 

Dermal exposure is the most common route of exposure. Benzyl benzoate occurs naturally in balsams of Peru and Tolu and other essential oils. It is also available in liquid, emulsion, and lotion dosage forms. 

Uses Wet granulation binder for oral solid dosage forms solubilizer and bioavailability enhancer of poorly soluble drugs crystal growth inhibitor, and rheological additives in soft-gelatin capsules, oral liquids and suspensions, parenterals, topical gels, creams, lotions and ophthalmic preps. 

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