Liquid chromatography software

Dionex Corporation - Manufacturers of liquid chromatography systems (IC and HPLC), chromatography software data systems, reversed-phase and ion-exchange columns, and accelerated solvent extraction systems... http //www.dionex.com. 

Guillemin, C. L., Problems and proposed solutions for on-line process liquid chromatography the software-driven chromatograph, Proc. Cont. Qua ., 1, 23, 1990. 

Figure 2. Software Modulea for size-exclusion liquid Chromatography...

A software filter which allows the removal of interference ions from drug metabolites in accurate mass liquid chromatography—mass spectrometry... 

Zhang, H. Zhang, D. Ray, K. A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/ mass spectrometric analyses. J. Mass Spectrom. 2003, 38, 1110-1112. 

Fig. 6.1.4 Components of the high-performance liquid chromatography (HPLC) system for oxidized pterins with column switching. The autosampler starts the chromatography software, which controls valves and pumps. Pump 3 is used only for rinsing the precolumn. Details of the three valves and their different positions are explained in Fig. 6.1.5...

Depending on the type of chromatography, optimisation can be fairly rapid. Optimisation in gas phase chromatography is easier than in liquid chromatography where the composition of the mobile phase plays a role. Computer software is available that has been specially designed to help determine the correct composition of the mobile phase. 

Liquid chromatography is now a mature technique. Instruments are reliable and increasingly computer assisted. Column-to-column reproducibility is ensured by most manufacturers. The quest for the universal detector is about to end with the advent of a sophisticated and miniaturized MS detector. Development of a method can be achieved in a rather short period with available software. The emphasis is on validation more than on how to handle it. Capillary columns are sure to improve, and the trend will be toward many parallel analyses. 

The coupling of LC (liquid chromatography) with NMR (nuclear magnetic resonance) spectroscopy can be considered now to be a standard analytical technique. Today, even more complex systems, which also include mass spectrometry (MS), are used. The question arises as to how such systems are handled efficiently with an increasing cost and a decreasing availability of skilled personal. LC-NMR and LC-NMR/MS combine the well-established techniques of LC, NMR and MS. For each of those techniques, various automation procedures and software packages are available and used in analytical laboratories. However, due to the necessary interfacing of such techniques, completely new demands occur and additional problems have to overcome. 

XCMS Scripps Center for Metabolomics Software for processing liquid chromatography-mass spectrometry-based metabolomics data (http //medin.scripps.edu/... 

I. Mohiar, Computerized design of separation strategies by reversed-phase liquid chromatography Development of DryLab software, J. Chromatogr. A 965 (2002), 175-194. 

S. V. Galushko, A. A. Kamenchuk, and G. L. Pit, Calculation of retention in reversed-phase liquid chromatography IV. ChromDream software for the selection of initial conditions and for simulating chromatographic behavior, I Chromatogr. A 660 (1994), 47-59. 

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