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Liposomes reticuloendothelial system

Allen, T. M., and Chonn, A. (1987). Large unilamellar liposomes with low uptake into the reticuloendothelial system, FEBS Lett., 223. 42-46. [Pg.316]

Kao, Y. J., and Juliano, R. L. (1981). Interaction of liposomes with the reticuloendothelial system Effects of blockade on the clearance of large unilamellar vesicles, Biochim. Biophys. Acta, 677, 453-461. [Pg.324]

Uliana, J. A., Gamble, R. C., and Baldeschwieler, J. D. (1983). Liposomal blockade of the reticuloendothelial system Improved tumor imaging with small unilamellar vesicles. Science. 220. 502-505. [Pg.332]

Tissue distribution of lipo-preparations. The tissue distribution of lipid microspheres in normal and pathologic animals was studied. Research into liposomes of similar size suggested that lipid microspheres accumulated preferentially in the reticuloendothelial system, inflammatory sites, or certain tumors. The distribution of lipid microspheres to these tissues has been found in our studies (7,2). Interestingly, our study showed that lipid microspheres accumulated, particularly at high concentrations, in damaged vascular walls such as atherosclerotic vascular walls. [Pg.265]

Several types of dmg carriers such as microspheres, liposomes, and polymer have been investigated to achieve targetable drug delivery, especially for anticancer drugs. However, nonselective scavenging of such carriers by the reticuloendothelial system (RES) is a serious problem even when monoclonal antibodies are used to carry the dmg [15,16]. [Pg.28]

Depending on their size and surface charge, parenterally administered liposomes interact with the reticuloendothelial system (RES) and provoke an immune response. [Pg.140]

A. Liposomal amphotericin B was approved by the US. Food and Drug Administration to treat visceral leishmaniasis. Pentavalent antimony compounds, pentamidine, amphotericin B, and aminosi-dine (paromomycin) have all been demonstrated efficacious here. The liposomal amphotericin appears to be better taken up by the reticuloendothelial system, where the parasite resides, and partitions less in the kidney, where amphotericin B traditionally manifests its toxicity. In addition to being better tolerated by patients, it has proved to be very effective in India, where resistance to antimony drugs is widespread. This patient appears to have acquired his infection there, where many infected patients develop darkening of the skin, hence the name kala-azar, or black sickness. Albendazole, an anthelmintic, has no role here. Atovaquone, a naphthoquinone, is used to treat malaria, babesiosis, and pneumocystosis. Pyrimethamine-sulfadoxine is used to treat malaria and toxoplasmosis. Proguanil inhibits the dihydrofolate reductase of malaria parasites and is used in combination with atovaquone. [Pg.619]

It is well established that size, charge, and chemical composition of liposomes affect their fate in vivo [306], To manipulate their biodistribution and/or drug release, liposomes of different structures have been prepared, including those sensitive to changes in pH [307, 308] or temperature [309,310]. Compared to soluble polymers discussed in previous chapters, liposomes, when applied i.v., are captured by a substantially greater extent by the specialized cells (macrophages) of the reticuloendothelial system (RES) [311]. The removal of liposomes from the bloodstream takes place by nonspecific endocytosis (phagocytosis) [312],... [Pg.110]

Palmitic acid is conjugated to glucuronic acid to form a reticuloendothelial system-avoiding liposome delivery system (79). Phospholipids such as phosphatidyl choline or phosphatidyl ethanolamine are used as constituents of lipid complexes or... [Pg.366]

The size of polymeric micelles, with an approximate diameter range of 20 to 60 nm, is smaller than achievable by liposomes and micro(nano)spheres. The smaller carrier systems are expected to show higher vascular permeability at target sites by a diffusion mechanism. Furthermore, the diameter range of the polymeric micelle systems is considered to be appropriate to evade renal excretion and nonspeciLc capture by the reticuloendothelial systems (RES). [Pg.334]

The clinical applications of liposomes are well known (Table 4). The initial success achieved with many liposome-based drugs has fueled further clinical investigations. One of the drawbacks of the use of liposomes is the fast elimination from the blood and capture of liposomal preparations by the cells of the reticuloendothelial system (RES), primarily in the liver. [Pg.366]


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See also in sourсe #XX -- [ Pg.205 ]




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