Lipoprotein drug effects

Kempen et al. [176] synthesized a water-soluble cho-lesteryl-containing trigalactoside, Tris-Gal-Chol (I), which when incorporated in lipoproteins allows the utilization of active receptors for galactose-terminated macromolecules as a trigger for the uptake of lipoproteins. The effect of increasing concentrations of Tris-Gal-Chol on the removal of LDL and HDL from serum and their quantitative recovery in the liver is shown in Fig. 13. These data show that lipoproteins containing Tris-Gal-Chol can be used as a liver-specific drug-carrier system. 

Agranulocytosis, neutropenia, thrombocytopenia, and erythroleu-kaemia have been reported during therapy with ticlopidine. Elevation of liver function tests are unusual with ticlopidine therapy, but occasionally cholestatic jaundice or hepatitis have been reported. Drug may increase total serum cholesterol, as well as LOL- and VLDL-cholesterol and other lipoproteins, without effecting HDL-cholesterol (1). 

Stamler, j., L. N. Katz, R. Pick, L. A. Lewis, I. H. Page, A. Pick, B. M. Kaplan, D. M. Berkson, and D. Century Effects of long-term estrogen therapy on serum cholesterol-lipid-lipoprotein levels and on mortality in middle-aged men with previous myocardial infarction. In Garattini, S., and R. Paoletti (Eds.) Proc. of the symposium on drugs effecting lipid metabolism, p. 432. Amsterdam Elsevier 1961. 

A class of important pharmacological compounds that are the most effective drugs for lowering plasma levels of low-density-lipoprotein (LDL)-cholesterol. 

Hayashi K, Kurushima H, Kuga Y, Shingu T, Tanaka K, Yasunobu Y, et al. Comparison of the effect of bezafibrate on improvement of atherogenic lipoproteins in Japanese familial combined hy-perlipidemic patients with or without impaired glucose tolerance. Cardiovasc Drugs Ther 1998 12 3-12. 

The effect of drug therapy on lipids and lipoproteins is shown in Table 9-5. 

Drug Mechanism of Action Effects on Lipids Lipoproteins... 

Treatment Various drugs are available that have different mechanisms of action and effects on LDL (cholesterol) and VLDL (triglycerides) (A). Their use is indicated in the therapy of primary hyperlipoproteinemias. In secondary hyperlipoproteinemias, the immediate goal should be to lower lipoprotein levels by dietary restriction, treatment of the primary disease, or both. 

It is considered the most effective drug for lowering levels of cholesterol, triglycerides, and very low-density lipoproteins in the plasma and for moderately increasing the number of high-density lipoproteins. It is used for treating hyperlipoproteinemia that cannot be corrected by a special diet or physical exertion. Synonyms of lovastatin are lovalip, meva-cor, mevinacor, and sivlor and those of mevastatin are CS-500 and ML-236 B. 

Y Kuroda, B Cao, A Shibukawa, T Nakagawa. Effect of oxidation of low-density lipoprotein on drug binding affinity studied by high-performance frontal analysis—capillary electrophoresis. Electrophoresis 22 3401—3407, 2001. 

Nicotinic acid has three special features as a hypolipidemic drug it has multiple beneficial effects on serum lipoproteins, it is the least expensive, and it is the least well tolerated. 

Drug Reduced CHD Risk Lipoprotein Affected Hyperlipoproteinemia Treated In Singly Combination Principal Adverse Effects... 

The answer is a. (Hardman, pp 875-898.) In type I hyperlipoproteinemia, drugs that reduce levels of lipoproteins are not useful, but reduction of dietary sources of fat may help. Cholesterol levels are usually normal, but triglycerides are elevated. Maintenance of ideal body weight is recommended in all types of hyperlipidemia. Clofibrate effectively reduces the levels of VLDLs that are characteristic of types 111, IV, and V hyperlipoproteinemia administration of cholestyramine resin and lovastatin in conjunction with a low-cholesterol diet is regarded as effective therapy for type 11a, or primary, hyperbetalipoproteinemia, except in the homozygous familial form. 

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