Levi-Montalcini

Levi-Montalcini, R (1987) The nerve growth factor 35 years later. Science 237 1154-1162. 

Levi-Montalcini, R. and Angeletti, R U. Nerve growth factor. Physiol. Rev. 48 534-569,1968. 

Rita Levi-Montalcini and Stanley Cohen Physiology/Medicine Nerve growth factor... 

Nerve growth factor (NGF) (Levi-Montalcini and Angeletti, 1968), is a well established trophic factor for the cholinergic neurons of the basal forebrain (Hefti, 1986 Williams et al., 1986). Moreover, in aged rodents and primates that have been demonstrated to be deficient in cortical ACh signaling, NGF has been shown both to increase ACh synthesis and improve memory deficits (Haroutunian... 

Interferons are arguably the oldest known cytokines, first described over 40 years ago by Isaacs and Lindenmann (1957). True, there were somewhat earlier publications in which phenomena now known to be mediated by cytokines or growth factors had been described (Bennett and Beeson, 1953 Levi-Montalcini and Hamburger, 1953), but, as pointed out by the science writer Stephen S. Hall (Hall, 1997), it was the first interferon publications that lit the fuse for an explosion of discoveries leading to the vast accumulation of knowledge about cytokines and the appreciation of their important biological function. 

Levi-Montalcini, R., and Hamburger, V. (1953). A diffusable agent of mouse sarcoma producing hyperplasia of sympathetic ganglia and hypemeurotization of viscera in the chick embryo. 

Nerve growth factor, NGF, was the first member of a family of growth factors of nerve cells. It was discovered by the Italian neurobiologist Rita Levi-Montalcini. Its active form... 

Menesini-Chen, M. G., Chen, J. S., and Levi-Montalcini, R., Sympathetic nerve fibers ingrowth in the central nervous system of neonatal rodent upon intracerebral NGF injections, Arch. Ital. Biol., 116, 53, 1978. 

Chen, J.S. Levi-Montalcini, R. Arch. Ital. Biol. 1970, 108, 503-537. 

Changeux, J. P. In 1988-1989 Fidia Research Foundation Rita Levi-Montalcini Neuroscience Award Lecture Raven New York, 1990 Vol. 4, pp 22-168. 

The role of NGF as a survival factor for sympathetic neurons has been demonstrated over the past forty years using numerous experimental systems (see Levi-Montalcini and Angeletti, 1968). It remains the only molecule to be unequivocally shown to be critical for neuron survival in vivo. The injection of anti-NGF antibodies into newborn mice results in the destruction of the sympathetic nervous system. Studies of the mechanism of action of NGF have resulted in it becoming the prototype of target-derived neurotrophic factors. In this model, the newly differentiated neurons sprout axons to their target fields, where there is a limited supply of a target-derived survival factor. It is... 

The best characterized factor shown to play a role in the development of sensory neurons is NGF (Levi-Montalcini and Angeletti, 1968 Thoenen and Barde, 1980 Levi-Montalcini, 1982). NGF most probably acts as a target-derived survival factor during the period of natural neuron death, as discussed in Section 3.6.1 for sympathetic neurons. The evidence for the time of action of NGF on sensory neurons comes from expression studies mRNA for NGF is first observed in the target tis-... 

Levi-Montalcini, R. (1982) Developmental neurobiology and the natural history of nerve growth factor. Annu. Rev. Neu-rosci. 5 341-362. 

The classical studies on NGF have shown that this molecule can cause the survival of sensoiy neurons (Levi-Montalcini and Angeletti, 1968) and has provided a paradigm for the in vivo investigation of the other putative survival factors. NGF... 

Hamburger, V. and Levi-Montalcini, R. (1949) Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions. J. Exp. Zool. 111 457-502. 

Levi-Montalcini, R., Aloe, L., Mugnaini, E., Oesch, F. and Teioenen, H. (1975) Nerve growth factor induces volume increase and enhances tyrosine hydroxylase synthesis in chemically axotomized sympathetic ganglia of newborn rats. Proc. Natl. Acad. Sci. USA 72 595-599. 

Nerve growth factor (NGF) is a potent protein identified more than 40 years ago, which exerts profound effects on components of the peripheral and central nervous systems. There are several excellent reviews covering many aspects of the extensive work that has allowed NGF to gain a prominent place in the study of the nervous system. most of which have addressed issues related to the known actions of NGF on sensitive neurons (Bradshaw, 1978, 1983 Greene and Shooter, 1980 Thoenen and Barde, 1980 Levi-Montalcini, 1987 Rush et al., 1992 Schecterson and Bothwell,... 

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