Sprouting, axonal

NT4/5 is expressed in muscle and this neurotrophin can support facial motor neurons as well as other populations of motor neurons. Interestingly, NT4/5 expression is regulated by the activity of the muscle and this neurotrophin stimulates axonal sprouting, suggesting that it acts as a muscle-derived trophic factor for motor neurons. 

Perez Y., Morin F., Beaulieu C., and Lacaille J. C. (1996). Axonal sprouting ofCAl pyramidal cells in hyperexcitable hippocampal slices of kainate-treated rats. Eur. J. Neurosci. 8 736-748. 

Cotman, C.W., Axon sprouting and regeneration, in Basic neurochemistry, Siegel, G.J. et al., eds., Lippincott-Raven, Philadelphia, 1999. 

Cheng HW, Tong J, McNeill TH (1998) Lesion-induced axon sprouting in the deafferented striatum of adult rat. Neurosci Lett 242 69-72. 

Finkelstein DI, Stanic D, Parish CL, Tomas D, Dickson K, Horne MK (2000) Axonal sprouting following lesions of the rat substantia nigra. Neuroscience 97 99-112. 

Rosenblad C, Kirik D, Bjorklund A (2000) Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model. Exp Neurol 767 503-516. 

Buckmaster, P.S., Zhang, G.F., andYamawaki, R. 2002. Axon Sprouting in a Model of Temporal Lobe Epilepsy Creates a Predominantly Excitatory Feedback C ltcmt. J Neurosci 22, 6650-6658. 

Mathem G, Bertram E, Babb T, Pretorius J, Kuhlman P, Spradlin S, et al. In contrast to kindled seizures, the frequency of spontaneous epilepsy in the limbic stains model correlates with greater aberrant fascia dentata excitatory and inhibitory axon sprouting, and increased staining forN-methyl-D aspartate, AMPA and GABA-A receptors. Neuroscience 1997 77 1003-1019. 

FGF-2 has been shown to protect mesencephalic dopaminergic neurons against the free radical-mediated toxicity of MPP and MPTP both in vitro (Otto and Unsicker, 1993a) and in vivo (Otto and Unsicker, 1990, 1993b Chadi et al., 1993a). The effects of FGF-2 incude partial compensation of loss of transmitters, induction of axonal sprouting, and marked improvement of motor performances. In vitro, these effects appear to be... 

The neuronal protein Thy-1, the smallest member of the Ig-family, represents a major fraction of the surface membrane protein on long axons. Thy-1 inhibits neurite outgrowth on mature astroglia and, thus, may stabilize neuronal connections and suppress axonal sprouting after injury (Tiveron et al., 1992). The astroglial-binding partner of Thy-1, however, is still unknown. 

Stichel, C.C. and Muller, H.W. (1994) Relationship between injury-induced astrogliosis, laminin expression and axonal sprouting in the adult rat brain. J. Neurocytol 23 615-630. 

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