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Leukemias CCRF-CEM

Astragaloside II, a cycloartane triterpene glycoside isolated from the Egyptian Astragalus spinosus, was tested at minimum of five concentrations 10-fold dilution against a total of 60 human tumor cell lines derived from seven cancer types (lung, colon, melanoma, renal, ovarian, brain and leukemia). The results indicated that the colon cancer (SW-620) and the leukemias (CCRF-CEM, HL-60) were the most sensitive cell lines [98]... [Pg.221]

IC50 (nM) (leukemia cells CCRF-CEM) 3.2 Plasma half life (min) (mice) 212 88... [Pg.134]

Bebawy et al. [186] demonstrated that CPZ (9) and vinblastine inhibited each other s transport in a human lymphoblastic leukemia cell line (CCRF-CEM/VLBioo). CPZ (9) reversed resistance to vinblastine but not to fluores-cently labeled colchicine and it increased resistance to colchicine. Colchicine was supposed to be transported from the inner leaflet of the membrane and vinblastine from the outer leaflet. CPZ (9) was assumed to be located in the inner membrane leaflet where it interacts with anionic groups of phospholipids and it may inhibit vinblastine transport via allosteric interactions. The authors concluded that transport of P-gp substrates and its modulation by CPZ (9) (or verapamil (79)) are dependent on substrate localization inside the membrane. Contrary to CPZ (9) location in the inner leaflet of the membrane, other modulators and substrates of P-gp were proved to be rather localized within the interface region of the membrane. The location of seven P-gp substrates and two modulators within neutral phospholipid bilayers was examined by NMR spectroscopy by Siarheyeva et al. [129]. The substrates and the modulators of P-gp were found in the highest concentrations within the membrane interface region. The role of drug-lipid membrane interactions in MDR and its reversal was reviewed in detail elsewhere [53,187]. [Pg.269]

The title substituted 6 phenylpurine bases and nucleosides 10—13, as well as some acetyl derivatives 8, were tested on their in vitro inhibition of the cell growth in the following cell cultures mouse leukemia L1210 cells (ATCC CCL 219) murine L929 cells (ATCC CCL 1) human cervix carcinoma HeLa S3 cells (ATCC CCL 2.2) and human T lymphoblastoid CCRF-CEM cell line (ATCC CCL 119). Only substituted 6-phenylpurine ribonucleosides 12 and their triacetates 8 exhibited significant activity in these assays (Table 1), while the bases 10 and 11, as well as the 2 amino 6 phenylpurine ribonucleosides 13, were entirely inactive. [Pg.3]

FIGURE 18.9 Concentration-effect curves for the thiopurine analogs, mercaptopurine (MP, open symbols) and thioguanine (TG, closed symbols). Effect is the percentage of cells killed in vitro relative to an untreated control in MOLT 4 (squares), CCRF-CEM (ti iangles), and Wilson (cn des) leukemia cell lines. TG is 10-fold more potent than is MP. (Reproduced with permission from Adamson PC, Poplack DG, Balis EM. Leukemia Res 1994 18 805-10.)... [Pg.294]

The methotrexate (MTX) analog (145) is prepared by condensing pyridopyrimidone carboxylic acid (143) with glutamic acid dimethyl ester (144). Testing of amide 145 in vitro against CCRF-CEM leukemia cells revealed that it is... [Pg.521]

Szabados, E. Duggleby, R.G. Christopherson, R.I. Metabolism of adenosine and deoxyadenosine by human erythrocytes and CCRF-CEM leukemia cells. Int. J. Biochem. Cell Biol., 28, 1405-1414 (1996)... [Pg.264]

Quinazolinones bearing an acetic acid ester moiety at A -3 or a mercapto-acetic acid ester substructure in position 2 have been evaluated as H -anti-histaminics (93AF(43)663J. Cytotoxic activities against CCRF-CEM human lymphoblastoid cells, HT-29 colon carcinoma cells and L1210/0 mouse leukemia cells have been reported for (E)-5-(2-acylvinyl)uracils (93MI(28)473). [Pg.237]

Adams, M., Efferth, T, Bauer, R. Activity-guided Isolation of Scopoletin and Isoscopoletin, the Inhibitory active principles towards CCRF-CEM Leukemia cells and multi-drug resistant CEM/ADR5000 cells, from artemisiae argyi. Planta Med. 72(9), 862-864... [Pg.104]

THP-1 (monocytic leukemia) MOLT-4 (T-cell lymphoma) CCR-CEM (T-cell lymphoma) CCRF-SB (B-cell lymphoma) HL-60 (promyelocytic leukemia) U-937 (promonocytic leukemia) Raji (Burkitt lymphoma) RPMI1788 (lymphoma)... [Pg.90]

See other pages where Leukemias CCRF-CEM is mentioned: [Pg.518]    [Pg.775]    [Pg.8]    [Pg.483]    [Pg.258]    [Pg.483]    [Pg.553]    [Pg.255]    [Pg.518]    [Pg.775]    [Pg.8]    [Pg.483]    [Pg.258]    [Pg.483]    [Pg.553]    [Pg.255]    [Pg.187]    [Pg.27]    [Pg.40]    [Pg.53]    [Pg.134]    [Pg.131]    [Pg.527]    [Pg.7]    [Pg.12]    [Pg.13]    [Pg.14]    [Pg.65]    [Pg.43]    [Pg.304]    [Pg.375]    [Pg.63]    [Pg.259]    [Pg.51]    [Pg.209]    [Pg.293]    [Pg.145]    [Pg.364]    [Pg.462]    [Pg.3396]    [Pg.93]    [Pg.221]    [Pg.221]    [Pg.197]    [Pg.303]    [Pg.1678]    [Pg.112]   
See also in sourсe #XX -- [ Pg.294 ]



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