Leukemia U937 cell

Iwama, K. et al., Apoptosis induced by arsenic trioxide in leukemia U937 cells is dependent on activation of p38, inactivation of ERK and the Ca2+-dependent production of superoxide, Int. J. Cancer, 92, 518, 2001. 

The expression of iNOS and the generation of NO in LPS-activated RAW 264.7 cells were inhibited by resveratrol [Murakami et al., 2003 Tsai et al., 1999], The compound significantly diminished the expression of tumor necrosis factor (TNF)-o mRNA in LPS-activated J774.2 macrophage cells [Kowalski et al., 2005] and peripheral blood leukocytes [Richard et al., 2005]. The expression of interleukin (IL)-8 protein and/or its mRNA in human monocytic leukemia (U937) cells [Shen et al., 2003] and human peripheral blood... 

Moon, D. O., Kim, M. O., Lee, J. D., and Kim, G. Y. (2008b). Gossypol suppresses NF-kappaB activity and NF-kappaB-related gene expression in human leukemia U937 cells. Cancer Lett. 264,192-200. 

Table 3. Growth inhibition in human monoblastic leukemia U937 cell by vitamin D analogues in combination with hydroxyurea (HU).

Haga N, Naito M, Seimiya H, Tomida A, Dong J, Tsuruo T. 2-Deoxyglucose inhibits chemotherapeutic drug-induced apoptosis in human monocytic leukemia U937 cells with inhibition of c-Jun N-terminal kinase 1/stress-activated protein kinase activation. Int J Cancer 1998 76 86 90. 

Palomba L, Sestili P, Cattabeni F et al. Prevention of necrosis and activation of apoptosis in oxidatively injured human myeloid leukemia U937 cells. FEBS Lett 1996 390(l) 91-94. 

TNDs and EGCG were also found to inhibit cell proliferation by inducing apoptosis in human leukemia U937 cells, human stomach cancer MICN45 cells, and human colon cancer WiDr cells (11). 

Chen, J.-Y, Lin, W.-Y, Wu, J.-L., Her, G.M., and Hui, C.-F. (2009) Epinecidin-1 peptide induces apoptosis which enhances antitumor effects in human leukemia U937 cells. Peptides, 30, 2365-2373. 

One of the first reports showing that DAG attenuates ceramide induced apoptosis used two human myeloid leukemia cell lines, namely HL-60 and U937. Exposure of HL-60 and U937 cells to SMase or lOpM ceU-permeable ceramides for 6 h resulted in DNA-laddering, a typical hallmark of apoptosis. This could be aboUshed by di-octanoylglycerol, a cell permeable... 

Concerning NO implication in hematopoietic cancer cells apoptosis, the situation is less clear. In U937 and HL60 cells, NO effects are very different although both cell lines have been established in culture from promyelocytic leukemia. NO-induced apoptosis in U937 cells (p53 negative cells) is a p53 and caspase independent pathway but is controlled by Bcl-2 [124]. In these cells NO inhibits caspase 3 by S-nitrosation... 

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