Legionnaires’ disease, treatment

Legionnaires disease treatment of Lipid-lowering drugs Local anesthetics... 

It is worthwhile drawing attention to health hazards associated with film infected water systems which also cause corrosion. Two of the most common are Legionnaires disease and so called humidifier fever . Because of strong adhesion of biofilms and diffusion rates through the film treatment based on cleaners and chemical sterilisers such as chlorine often fail similar considerations apply to other systems in industry, e.g. food, paint, oil and gas are examples where biofilm activities have given massive problems. 

Although erythromycin is a well-established antibiotic, there are relatively few primary indications for its use. These indications include the treatment of Mycoplasma pneumoniae infections, eradication of Corynebacterium diphtheriae from pharyngeal carriers, the early preparox-ysmal stage of pertussis, chlamydial infections, and more recently, the treatment of Legionnaires disease, Campylobacter enteritis, and chlamydial conjunctivitis, and the prevention of secondary pneumonia in neonates. 

NOTE In Europe sophisticated and computerized equipment utilizing HOBr generation has been marketed by some major water treatment service companies as a suitable system for the control of Legionella pneumophila, and thus control of the risk of contracting legionellosis (legionnaires disease). These systems have proved to be popular, if expensive, with operators of some major city building complexes. 

Cases of Legionnaires disease that occur in conjunction with an outbreak, or epidemic, are more likely to be diagnosed quickly. Early diagnosis aids effective and successful treatment. During epidemic outbreaks, fa-... 

Other, nonlabeled uses of rifampin include the treatment of serious infections such as endocarditis and osteomyelitis caused by methicillin-resistant 5. aureus or 5. epidermidis. Legionnaires disease when resistant to eiythromycin, and prophylaxis of H. injluenaie-induced meningitis. 

Oral/IV use for treatment of infections of the respiratory tract, skin and skin structure, and STDs caused by susceptible organisms treatment of pertussis, diphtheria, erythrasima, intestinal amebiasis, conjunctivitis of the newborn, Legionnaires disease, listeriosis, nongonococcal urethritis, pneumonia of infancy, urogenital infections during pregnancy treatment of acute pelvic inflammatory disease, syphilis, uncomplicated urethral, endocervical, or rectal infections in adults prevention of attacks of rheumatic fever prevention of bacterial endocarditis. 

A cydocarbonate moiety is formed on a macrolide scaffold during the synthesis of an intermediate of erythromycin A derivatives. Erythromycin A is a safe and effective antibiotic for the treatment of Gram-positive pathogens, and, in particular, it is the drug of choice for the treatment of Legionnaires disease. Erythromycin A, how-... 

The antibacterial effect of metal ions and especially silver, copper and zinc ions is well known. Silver and silver ions are used in medicinal treatments ranging from severe burns to Legionnaires Diseases. Silver-based products are also applied in water purification processes. Metal ions achieve their antibacterial effect by two mechanisms First the metal ions influence the electrochemical potential between the internal and external parts of the cell, and second, after penetration of ions into the cell, they compete with other essential ions like magnesium, calcium and potassium and they aggregate with thiol groups of enzymes and proteins. 

Westerman EL, McDonald J. Tularemia pneumonia mimicking Legionnaire s disease Isolation of organisms on CYE agar and successful treatment with erythromycin. South Med J. 1983 76 1169-1171. 

---