Diseases, isolation

Menkes, J. (1959) Maple syrup disease isolation and identification of organic acids in the urine. 

Chronic kidney disease Isolated systolic hypertension... 

Dancis, J., Levitz, M., Westall, R. (1960) Maple syrup urine disease branched-chain keto-aciduria. Pediatrics 25, 72-79. Menkes, J.H. (1959) Maple syrup disease isolation and identification of organic acids in the urine. Pediatrics 23, 348-353. 

Management of infectious disease—isolation and precaution measures... 

Figure 1.5 Flyperenhancement patterns found in clinical ischaemic disease. Isolated mid-wall or subepicardial practice. If hyperenhancement is present, the hyperenhancement strongly suggests a non-ischaemic ...

Loeb, M.R. and Smith, D.H. 1980, Outer membrane protein composition in disease isolates of Haemophilus influenzae pathogenenic and epidemiological implications. Infection Immunity 30 709-717. 

Westerman EL, McDonald J. Tularemia pneumonia mimicking Legionnaire s disease Isolation of organisms on CYE agar and successful treatment with erythromycin. South Med J. 1983 76 1169-1171. 

UzMAN, L. L. Polycerebrosides in Gaucher s disease isolation, composition and physical properties. Arch. Path. 55, 181 (1953). 

CgHiiNO. M.p. 282 C (decomp.). The naturally occurring substance is laevorotatory. It is an amino-acid isolated from various plant sources, but not found in the animal body. It is formed from tyrosine as the first stage in the oxidation of tyrosine to melanin. It is used in the treatment of Parkinson s disease. 

Although the compounds were isolated in quantities of only a few milligrams per kilogram of cmde plant leaves, extensive work on a variety of animal tumor systems led to eventual clinical use of these bases, first alone and later in conjunction with other materials, in the treatment of Hodgkin s disease and acute lymphoblastic leukemia. Their main effect appears to be binding tightly to tubuHn, the basic component of microtubules found in eukaryotic cells, thus interfering with its polymerization and hence the formation of microtubules required for tumor proliferation (82). 

Secondary immunodeficiencies (9) are much more common than primary ones and frequently occur as a result of immaturity of the immune system in premature infants, immunosuppressive therapy, or surgery and trauma. Illnesses, particularly when prolonged and serious, have been associated with secondary immunodeficiencies, some of which may be reversible. Acquked immune deficiency syndrome (AIDS) (10—12) may be considered a secondary immunodeficiency disease caused by the human immunodeficiency vimses HIV-1 or HIV-2. Hitherto unknown, the disease began to spread in the United States during the latter part of the 1970s. The agent responsible for this infection has been isolated and identified as a retrovims. 

Epidemiological studies of nickel-producing and nickel-using workers seldom indicate excess mortaUty from nonmalignant respiratory disease. Evidence for such effects exists mainly as a few reports of isolated incidents of asthma, pulmonary fibrosis, chronic bronchitis, and emphysema in nickel workers. Nickel may or may not play a causal role in these incidents (131). 

In 1913, Goldberger demonstrated that pellagra was due to a dietary deficiency. Pellagra had been eadier described by Thiery, who had coined the term mal de la rosa for this disease. Several decades later, Elvehjem and co-workers isolated nicotinamide from a Hver extract and identified it as a peUagra-preventing factor (1). 

Isolation and Structure Determination. The isolation and stmcture elucidation of vitamin D are closely related to the efforts to understand and cure tickets and related bone diseases. The advent of the use of soft coal, the migra tion of people to cities, and the tendency of people and animals to spend less time in sunshine caused a decline in the abiUty of populations to synthesize sufficient quantities of vitamin D. This led to the increased incidence of tickets, beginning around the mid-1600s (3). 

Aristeromycin. Aristeromycin (36), the first carbocyhc analogue of adenosine, was isolated from the culture filtrates of S. citricolor as part of a search for inhibitors of bacterial leaf blight (1—4). A herbicidaHy active hypoxanthine analogue of (36), coaristeromycin, has also been isolated (108). Several chemical syntheses of (36) have appeared (1—4,109). It inhibits Aanthomonas OTjc e and Eyricularia bacterial leaf blight, blast disease of rice plants, and... 

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