Lauterbur, Paul

In 2002,60 million MRI procedures were performed. The 2003 Nobel Prize in Physiology or Medicine was awarded to chemist Paul C. Lauterbur and physicist Sir Peter Mansfield for their contributions in developing magnetic resonance imaging. 

The use of NMR for imaging was demonstrated in 1973 by Paul Lauterbur for medical applications [Lau 1 ] and by Peter Mansfield [Man 1 ] for materials. Before that the potential of NMR for medical diagnostics had already been recognized by Raymond Damadian in 1971 [Daml]. 

Since the publication of the first edition of this book, there have been many important developments in the field of NMR spectroscopy. These developments have included the award of two Nobel prizes in 2002 to Kurt Wiithrich for his major contributions to biomolecular NMR spectroscopy and in 2003 to Paul C. Lauterbur and Sir Peter Mansfield for their work on MRI, both awards confirming the scientific importance of the general method and its wide application. Consequently, this second edition has been extended to incorporate a number of these pulse sequence developments. Nevertheless, to understand these sophisticated methods it is still necessary that students and newcomers start with the basic experiments and proceed on a step-by-step basis. In this context NMR-SIM is an outstanding, user-friendly simulation program that may be used by both the novice and the expert as an efficient training tool. Therefore, it is no surprise that BRUKER have included NMR-SIM in their latest spectrometer software package TOPSPIN. 

Fig. 14.71). This sensitive and nondestructive method for providing images of various parts of the body has revolutionized medical diagnosis. The discoverers of this technique, Paul Lauterbur of the University of Illinois and Peter Mansfield of the University of Nottingham, were awarded the Nobel Prize for medicine in 2003.

MRI has none of the disadvantages of X-rays. Diseased tissue appears very different from healthy tissue, resolving overlapping structures at different depths in the body is much easier, and the radio frequency radiation is not harmful to humans in the doses used The technique has had such a profound influence on the modern practice of medicine that Paul Lauterbur, a chemist, and Peter Mansfield, a physicist, were awarded the 2003 Nobel Prize in Physiology or... 

The original name given to MRI by its inventor, Paul Lauterbur. 

The concept of molecules that are able to change water relaxation times comes from the early times of MRI, when Bloch showed that Fe(N03)3 had the ability to decrease water proton and T2 [12]. Later in 1978, Paul Lauterbur considered... 

Nobel lecture entitled All science is interdisciplinary - From magnetic moments to molecules to men was dehvered by Paul C. Lauterbur, a winner of the Nobel Prize for Physiology or Medicine in 2003. In this lecture. Prof. Lauterbur described important facets of his life and his sdentific career that led him from silicones to the clinical application of NMR spectroscopy and later to the question of how chemists can help in explaining biology. 

Piofessor Paul C. Lauterbur (1929-2007), University of Illinois at Uibana-Chtunpaign, Illinois Professor Sir Peter Mansfield (b. 1933), University of Nottingham, UK. 

Many of us can recall the great intellectual excitement that accompanied the publication of the early NMR experiments in 1973 showing how spatial information can be encoded into NMR signals. In particular, the simple approach adopted by Paul Lauterbur of using held gradients to produce the... 

In the earliest days of C spectroscopy when Paul Lauterbur and Jake Stothers were using rapid passage, dispersion mode scans to overcome the relaxation problem, the "anomalous" shielding property of iodine was already recognized through use of the precious C-enriched methyl iodide sample as an external reference with a resonance at the extreme high field end of the C range. 

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