Mansfield, Peter

As noted earlier, NMR lines from solids are very broad, but as early as 1958 Raymond Andrew and Irving Lowe independently showed that rapid spinning of the sample under certain conditions can reduce the line width. During the period 1965—1975 a number of clever new methods were developed (primarily in the laboratories of John Waugh, Alex Pines, Peter Mansfield, and Robert Vaughn) to employ both pulsed and continuous wave NMR methods to obtain narrow lines in solids. We shall describe the basic ideas behind these techniques and give some illustrations of their application. 

In 2002,60 million MRI procedures were performed. The 2003 Nobel Prize in Physiology or Medicine was awarded to chemist Paul C. Lauterbur and physicist Sir Peter Mansfield for their contributions in developing magnetic resonance imaging. 

The use of NMR for imaging was demonstrated in 1973 by Paul Lauterbur for medical applications [Lau 1 ] and by Peter Mansfield [Man 1 ] for materials. Before that the potential of NMR for medical diagnostics had already been recognized by Raymond Damadian in 1971 [Daml]. 

Since the publication of the first edition of this book, there have been many important developments in the field of NMR spectroscopy. These developments have included the award of two Nobel prizes in 2002 to Kurt Wiithrich for his major contributions to biomolecular NMR spectroscopy and in 2003 to Paul C. Lauterbur and Sir Peter Mansfield for their work on MRI, both awards confirming the scientific importance of the general method and its wide application. Consequently, this second edition has been extended to incorporate a number of these pulse sequence developments. Nevertheless, to understand these sophisticated methods it is still necessary that students and newcomers start with the basic experiments and proceed on a step-by-step basis. In this context NMR-SIM is an outstanding, user-friendly simulation program that may be used by both the novice and the expert as an efficient training tool. Therefore, it is no surprise that BRUKER have included NMR-SIM in their latest spectrometer software package TOPSPIN. 

Fig. 14.71). This sensitive and nondestructive method for providing images of various parts of the body has revolutionized medical diagnosis. The discoverers of this technique, Paul Lauterbur of the University of Illinois and Peter Mansfield of the University of Nottingham, were awarded the Nobel Prize for medicine in 2003.

MRI has none of the disadvantages of X-rays. Diseased tissue appears very different from healthy tissue, resolving overlapping structures at different depths in the body is much easier, and the radio frequency radiation is not harmful to humans in the doses used The technique has had such a profound influence on the modern practice of medicine that Paul Lauterbur, a chemist, and Peter Mansfield, a physicist, were awarded the 2003 Nobel Prize in Physiology or... 

The Sir Peter Mansfield Magnetic Resonance Imaging Centre,... 

Echo-planar imaging (Peter Mansfield) British physicist Mansfield first develops the echo-planar imaging (EPI). 

Piofessor Paul C. Lauterbur (1929-2007), University of Illinois at Uibana-Chtunpaign, Illinois Professor Sir Peter Mansfield (b. 1933), University of Nottingham, UK. 

---