Larva migrans

Minte2ol, soluble in ethanol cutaneous larva migrans. ... 

Beaver, P.C. (1962) Toxocarosis (visceral larva migrans) in relation to tropical eosinophilia. Bulletin de la Societe de Pathologie Exotique 55, 555—576. 

Nichols, R.L. (1956) The etiology of visceral larva migrans. I. Diagnostic morphology of infective second-stage Toxocara larvae. Journal ofParasitology 42, 349-362. 

Cutaneous larva migrans (creeping eruption) Ancylostoma braziliense and others Thiabendazole, Albendazole, or Ivermectin-... 

Several benzimidazoles are in use for the treatment of helminthic infections. Three of these, mebendazole, thiabendazole and albendazole, are described in this section. They have a broad range of activity against many nematode and cestode parasites, including cutaneous larva migrans, trichinosis, disseminated strongyloidiasis, and visceral larva migrans. A fourth, triclabendazole, is considered as the drug of choice for Easciola hepatica therapy. 

Mebendazole is used primarily for the treatment of A. lumbricoides, T. trichiura, E. vermicularis, and hookworm infections, in which it produces high cure rates. It is an alternative agent for the treatment of trichinosis and visceral larva migrans. Owing to its broad-spectrum anthelmintic effect, mixed infections (ascariasis, hookworm infestation, or enterobiasis in association with trichuriasis) frequently respond to therapy. High doses have been used to treat hydatid disease, but albendazole is now thought to be superior. 

Unlabeled Uses Cutaneous larva migrans, filariasis, pediculosis, scabies, VJucfiereria bancrofti... 

Visceral larva migrans PO 50 mg/kg/day ql2h for 7 days. Maximum 3 g/day. 

The answer is c. (Hardman, p 1688.) Thiabendazole has been shown to be effective against Strongyloides, cutaneous larva migrans, and Trichuris. Adverse effects consist of nausea, vertigo, headache, and weakness. Treatment usually involves oral administration for several days. It has been found to be ineffective in Ascaris, N. americanus, E. vermicularis, and T. saginata. 

Thiabendazole is an alternative to ivermectin or albendazole for the treatment of strongyloidiasis and cutaneous larva migrans. 

The standard dosage, 25 mg/kg (maximum 1.5 g) twice daily, should be given after meals. Tablets should be chewed. For strongyloides infection, treatment is for 2 days. Cure rates are reportedly 93%. A course can be repeated in 1 week if indicated. In patients with hyperinfection syndrome, the standard dose is continued twice daily for 5-7 days. For cutaneous larva migrans, thiabendazole cream can be applied topically, or the oral drug can be given for 2 days (although albendazole is less toxic and therefore preferred). 

Nakamura, N., Kiuchi, F., Tsuda, Y. and Kondo, K. (1988) Studies on crude drugs effective on visceral larva migrans. V. The larvicidal principle in mace (aril of Myristica fragrans). Chemical and Pharmacological Bulletin 36(7), 2685. 

Ocular larva migrans, the other form of this disease, is most often seen in children at an average age of 7.5 years. 

Varying retinal manifestations of ocular larva migrans depend on the site of lodgment of the larva, severity of the individual reaction, and the stage at which the eye is examined. Ocular presentations are typically unilateral, with symptoms ranging from none to profound vision loss. It should be noted that ocular larva migrans rarely coexists with VLM. 

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