Large-scale production systems

The potential advantages far outweigh the disadvantages, and the development work is continuing in laboratories at many universities and some companies. To the best of our knowledge, there is no large-scale production system in use today for UV-cur-able tape casting. 

Care must be taken when developing mixing strategies at a small scale, as it is very easy to use excessively high specific power inputs, which cannot be replicated economically in large scale production systems. 

Biopolymer Extraction. Research interests involving new techniques for separation of biochemicals from fermentation broth and cell culture media have increased as biotechnology has grown. Most separation methods are limited to small-scale appHcations but recendy solvent extraction has been studied as a potential technique for continuous and large-scale production and the use of two-phase aqueous systems has received increasing attention (259). A range of enzymes have favorable partition properties in a system based on a PGE—dextran—salt solution (97) ... 

MammaBan. For mammalian proteins, mammalian cells offer the most natural host for expression. Problems of incorrect processing and post-translational modification are avoided using these cells. Mammalian cells are usually grown in continuous cell culture, reducing the variabiUty in results (see Cell CULTURE technology). Moderate-level production of native protein is possible. The procedure, however, is slow and very cosdy, and the level of protein expression is low. Thus large-scale production of proteins in mammalian cells is not practical. When low quantities of protein are sufficient, this system offers the several advantages described. 

An airlift tank of 1000-2000 L would be sufficient to sprout the 9000 kg of seeds produced per year in a 1-ha greenhouse. Experimentally, a 70-L airlift tank has been used and a few hundred kg of sprouts have been produced. In the food industry, sprouts are currently produced at the rate of 500 tons per year in the USA and 400 tons per year in Japan. The seeds are harvested easily and the volume of sprout material is manageable because harvesting whole plants is not necessary. This avoids the processing of large volumes of transgenic material. Characteristic benefits of our system in terms of large-scale production can be summarized as follows ... 

---