Laing, Michael

Pilato LA, Michael JM (1994) Advanced composite materials, Springer, Berlin Heidelberg New York, Chap 2... 

Zwelling LA, Michaels S, Kerrigan D, Pommier Y et al. 1982 Protein-associated deoxyribonucleic acid strand breaks produced in mouse leukemia LI210 cells by ellipticine and 2-methyl-O-hydroxy- ellipticinium. Biochem Pharmacol 31 3261-3267... 

Zwelling LA, Michaels S, Erickson LC, Ungerleider RS, Nichols M, Kohn KW (1981) Biochemistry 20 6553... 

Lar LA, Michael K Christoffer HA, Peter BH, Mette KZ, Klaus H, Gisela S (2008) Muscle activation during selected strength exerdses in women with chronic neck muscle pain. Physical Therapy 88(6) 703-711. 

I acknowledge many scholars of the periodic table from diverse fields, including Peter Atkins, Henry Bent, Bernadette Bensaude, Nathan Brooks, Edwin Constable, John Emsley, Michael Gordin, Ray Hefferlin, William Jensen, Herbert Kaesz, Masanori Kaji, Maurice Kibler, Bruce King, Mike Laing, Laurence Lavelle, Guillermo Restrepo, Dennis Rouvray, Oliver Sacks, Eugen Schwarz, Philip Stewart, Mark Winters and many others. 

D. Michael Badine 3 ch de la Dole 1279 Chavannes de Bogis Switzerland... 

Other nucleophiles add to conjugated systems to give Michael-type products. Aniline derivatives add to conjugated aldehydes in the presence of a catalytic amount of DBU (p. 488). Amines add to conjugated esters in the presence of InCla, La(OTf)3, or YTb(OTf)3 at 3kbar, for example, to give P-amino esters. This reaction can be initiated photochemically. An intramolecular addition of an amine unit to a conjugated ketone in the presence of a palladium catalyst, or... 

Maier, Michael. Maier - Laws of the Fraternity of the Rosy Cross. rhttp //www.levitv.com/alchemv/maier la.htmll. 

Hunter, Michael Cyril William. Elias Ashmole, 1617-1692 the founder of the Ashmolean Museum and his world a tercentenary exhibition, 27 April to 31 July 1983 / compiled by Michael Hunter in conjunction with Kenneth Garlick and N. J. Mayhew Bodleian exhibition entries by Albinia De la Mare. Oxford Ashmolean Museum, 1983. xi, 92p. ISBN 0907849008... 

Michael Davis, Department of Organic Chemistry, La Trobe University, Bundoora, Victoria 3083, Australia (47)... 

Initially, a complex of nitroalkene (42) with LA (A) is reversibly formed. The efficient concentration of the latter is determined by the reaction conditions and the nature of heterodiene (42) and LA. This complex acts as a Michael substrate and adds alkene (43) to give bipolar adduct B, which undergoes cycliza-tion to give cationic intermediate C. The latter eliminates LA to yield target nitronate (35). In the case of nonconcerted cycloaddition, ionic intermediate B can undergo different isomerization reactions, some of which are considered below. The stereoselectivity of the process depends on the reactive conformation... 

Professor Seebach and coworkers (96) used silyl enolate (203) containing an additional C,C double bond in the Michael reaction with a-nitroalkene (204) in the presence of chiral LA (Scheme 3.146). 

The author would like to thank A1 Barckhoff, PerkinElmer LAS, for helping clarify some of the nuances in the ever-evolving system validation process and for providing valued expertise on this topic. Michael Dong of Purdue Pharma, should also be thanked for helping maintain a clear focus on the subject matter. Finally, the author would like to thank PerkinElmer LAS for making available the opportunity to write this chapter. 

ShotweU OL, Stodola EH, Michael WR, Lindenfelser LA, Dworschack RCi Pridham TG. (1958) Antibiotics against plant disease. III. Duramycin, anew antibiotic from Streptomyces Cinnamomeus forma Azacoluta. J Am Chem Soc 80 3912-3915. 

Sendivogius, Michael (Michal S dziwoj). Cosmopolite, ou nouvelle lumiere chim-ique, divisez en douse traitez, avec un dialogue de Mercure, de I alchymiste et de la Nature. Paris Jean d Houry, 1569. 

Michael S. Lajiness Structural and Computational Sciences, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana, USA Raymond L.H. Lam Department of Data Exploration Sciences, GlaxoSmithKline, King of Prussia, Pennsylvania, USA Barry K. La vine Department of Chemistry, Clarkson University, Potsdam, New York, USA... 

The groups of Rueping [25] and Gong [26] have developed the aza-hetero-Diels-Alder reaction of aryl imines and cyclohexenone to give isoquinuclidines in good endojexo selectivities and high yields and ee s by 1 and la, respectively (Scheme 5.13). In the presence of acid, cyclohexenone enolizes to afford the dienol which subsequently undergoes a Mannich reaction with the protonated aldimine followed by intramolecular aza-Michael addition to produce the formal Diels-Alder adducts. 

Fig. 42. The structure of the zinc finger domain of the Xenopus Xfin protein, as determined by solution NMR methods. [Courtesy of Michael Pique and Peter E. Wright, Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California. From Lee et al., Science 245, 635-637, 11 August 1989. Copyright 1989 by the American Association for the Advancement of Science.]...

A -compounds (130) with CH2NO2 leads to the nitrocyclopropanes (131) by Michael addition and elimination of HBr. Various transformations of the la-nitromethyl-3-oxo-compounds (132) include its conversion into the la-formyl-3-oxo-compound (133), which on hydride reduction was converted into the tetra-hydrofuran (134). ... 

The Michael attack of the enamine moiety in the 3,6-dihydro-2//-l,3-thiazine 149 on a-phthalimido acrylic acid affords the cyclic product 152, most probably through the intermediate 150. Support for the mechanisms comes from the isolation of the 5,6,7,8-tetrahydro-la//-thiireno[2,3-f]indolizine 151 in 10% yield (Scheme 10) <1999J(P1)3565>. 

Moffitt, ]. F. Alquimia y las artes. In S. Sebastian, ed. Alquimia y Emblemdtica La Fuga de Atalanta de Michael Maier. Madrid Tuero, 1989. 10-25. 

Sebastian, S., ed. Alquimia y Emblemdtica La Fuga de Atalanta de Michael Maier. 

When the heavier group 1A and 2A metals are heated in an excess of oxygen, they fr Michael Laing, "The Three... 

Shibasaki made several improvements in the asymmetric Michael addition reaction using the previously developed BINOL-based (R)-ALB, (R)-6, and (R)-LPB, (R)-7 [1]. The former is prepared from (R)-BINOL, diisobutylaluminum hydride, and butyllithium, while the latter is from (R)-BINOL, La(Oz -Pr)3, and potassium f-butoxide. Only 0.1 mol % of (R)-6 and 0.09 mol % of potassium f-butoxide were needed to catalyze the addition of dimethyl malonate to 2-cy-clohexenone on a kilogram scale in >99% ee, when 4-A molecular sieves were added [15,16]. (R)-6 in the presence of sodium f-butoxide catalyzes the asymmetric 1,4-addition of the Horner-Wadsworth-Emmons reagent [17]. (R)-7 catalyzes the addition of nitromethane to chalcone [18]. Feringa prepared another aluminum complex from BINOL and lithium aluminum hydride and used this in the addition of nitroacetate to methyl vinyl ketone [19]. Later, Shibasaki developed a linked lanthanum reagent (R,R)-8 for the same asymmetric addition, in which two BINOLs were connected at the 3-positions with a 2-oxapropylene... 

Complex LSB 9 is readily prepared either by the reaction of La(0 Pr)3 with 3 equiv. of B1NOL followed by the addition of NaO Bu (3 equiv.) or by the reaction of LaCl nfLO with sodium binaphthoxide. The complex 9 is stable to oxygen and moisture and has been proven to be effective in the catalytic Michael reaction of various enones with either malonates or p-keto esters. The Michael adducts with up to 92% ee were obtained in almost quantitative yield. Typical results with malonates are summarized in Table 8D.1 (Ln = lanthanide) [18], In general, the use of THF as solvent gave the best results except for the case of the LSB-catalyzed reaction of rmns-chalcone with dimethyl malonate, wherein the use of toluene was essential to give the adduct with good enantiomeric excess. The effects of the central metal (La, Pr, and Gd) on asymmetric induction were also examined in the same reaction, and LSB was found to be the best catalyst. 

Other nucleophiles such as nitromethane can also be used for this reaction. Thus, by the catalysis of (fl)-LPB (LaK3tris((/ )-binaphthoxide) (20 mol %), in which La works as a Lewis acid and K-naphthoxide works as a Brpnsted base, nitromethane reacted with chalcone to give the Michael adduct in 85% yield and 93% ee (Scheme 8D.8) [22], Addition of BuOH (120 mol %) gave a beneficial effect on the reactivity as well as the enantioselectivity of this reaction. 

Acetylacetone la (10 mmol), metliyl vinyl ketone 2a (10 mmol) and bismuth trichloride (0.32 g, 10% mol) were mixed together without solvent in an Erlen-meyer flask and placed in a commercial microwave oven (operating at 2450 MHz frequency) and irradiated for 15 min. The reaction mixture was allowed to reach room temperature and extracted with chloroform. Removal of solvent and the residue on purification by passing through a short column of silica gel using chloroform as eluent, affords the Michael adduct 4a in 90% yield without tlie formation of any side products. Similarly cadmium iodide (10% mol) was used in place of bismuth trichloride and the corresponding Michael adduct was isolated in 85% yields. 

Michael S. VanNieuwenhze Department of Chemistry and Biochemistry University of California, San Diego La Jolla, California 92093... 

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