Acidophilus

Allenes are compounds with adjacent carbon-carbon double bonds. Many allenes are chiral, even though they don t contain chirality centers. Mycomycin, for example, a naturally occurring antibiotic isolated from the bacterium Nocardia acidophilus, is chiral and has = -130. Explain why mycomycin is chiral. Making a molecular model should be helpful. 

To reduce the risk of superinfection, take yogurt, buttermilk, or acidophilus capsules. 

Lactobacillus acidophilus ATCC 4356 slpA slpB 444/24 456 (silent) O X89375 X89376... 

SWANSON K S, GRIESHOP C M, FLICKINGER E A, BAUER L L, WOLF B W, CHOW J, GARLEB K A, WILLIAMS J A, FAHEY G c Jr (2002b) FructooUgosaccharides and Lactobacillus acidophilus modify bowel function and protein catabolites excreted by healthy hmnans. J Nutr. 132 3042-50. 

Probiotics, such as Lactobacillus acidophilus or Bifidobacterium, may offer possible benefit, based on the rationale that modification of the host flora may alter the inflammatory response. Some evidence exists for improvement in disease symptoms, but further well-controlled trials are needed.26... 

Although study results are conflicting, the daily consumption of active Lactobacillus acidophilus may reduce recurrence. One study found that the daily ingestion of 8 ounces of yogurt produced a threefold reduction in the incidence of infection,8 while other studies found no difference in infection rates in women who ingested yogurt.9,10... 

Bees and ants are not the only critters that attack using acid. Bacteria, such as those found in plaque, do, too. Saliva usually keeps the mouth at a pH of about 6.8. Any pH of 6.0 or higher does not cause the teeth any problems. Plaque, a bacteria-containing film that builds up on teeth, can cause that pH to plummet. That is because it contains bacteria such as Streptococcus mutans, Lactobacillus casei, and Lactobacillus acidophilus that feed on sugars and make lactic acid. These conditions can lower the pH in the mouth to 5.5 or less. 

Laland SG, Serck-Hanssen G (1964) Synthesis of pyrimidin-2-one deoxyribosides and their ability to support die growth of the deoxyriboside-requiring organism lactobacillus acidophilus r26. Biochem J 90 76-81... 

The main species currently considered or used for the development of probiotic products in pig and poultry are L. reuteri, L. acidophilus, L. rhamnosus, L. plantarum, L. delbrueckii subsp. bulgaricus, L. lactis and L. brevis (Massi et al 2006 Bilgili and Moran, 1990). 

A Lactobacillus strain was recently shown to inhibit competitively adhesion of enteropathogenic E. coli to pig ileum and interfered with bacterial attachment to the mucosal layer of ileal conducts (Blomberg et al., 1993). Although L. acidophilus inhibits the adhesion of several enteric pathogens to human intestinal cells in culture, when pathogen attachment preceded L. acidophilus treatment, no inhibitory interference occurred indicating that steric hindrance of site occupation is important in the inhibition of adhesion. Thus, therapeutic use is likely to be limited to preventive application of probiotics. 

Babinska I., Rotkiewicz T. and Otrocka-Domagala I. (2005). The effect of Lactobacillus acidophilus and Bifidobacterium spp. administration on the morphology of the gastrointestinal tract, liver and pancreas in piglets . Pol J Vet Sci, 8(1), 29-35. 

Gmeiner M., Kniefel W., Kulbe K.D., Wouters R., De Boever P., Nollet L. and Verstreate V. (2000). Influence of a synbiotic mixture consisting of Lactobacillus acidophilus 74—2 and a frue loo I i go s acc h ari dc preparation on the microbial ecology sustained in a simulation of the human intestinal microbial ecosystem (SHIME reactor) . Appl Microbiol Biotechnol, 53, 219-223. 

Kinouchi T, Kataoka K, Bing SR, Nakayama H, Uejima M, Shimono K, Kuwahara T, Aki-moto S, Hiraoka I, Ohnishi Y Culture supernatants of Lactobacillus acidophilus and Bifidobacterium adolescentis repress ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug by suppressing unbalanced growth of aerobic bacteria and lipid peroxidation. Microbiol Immunol 1998 42 347-355. 

Lactobacilli used have included a commercial mixture of Lactobacillus acidophilus and Lactobacillus bulgaricus (Lactinex ) and Lactobacillus GG. decreased AAD in adults receiving amoxicillin (3.3%) compared to placebo (21%), but the difference was not statistically significant [69]. A study in children receiving amoxicillin failed to demonstrate a significant decrease in AAD with this probiotic mixture [70], Variability in lots may explain differences in efficacy in many trials [71], Lactobacillus GG may have a better efficacy than this probiotic mixture in... 

Several probiotic organisms have been shown to adhere to the intestinal mucosa (Jacobsen et ah, 1999). For example, Lactobacillus acidophilus... 

Bernet, M. F., Brassart, D., Neeser, J. R., and Servin, A. L. (1994). Lactobacillus acidophilus Lai binds to cultured human intestinal cell lines and inhibits cell attachment and cell invasion by enterovirulent bacteria. Gut 35, 483-489. 

Hiraishi A, Nagashima KVR Katayama Y. 1998. Phylogeny and photosynthetic featnres of Thiobacillus acidophilus and related acidophilic bacteria its transfer to the genns Acidiphilium as Acidiphilium acidophilum comb. nov. Int J Syst Bacteriol 48 1389-98. 

Table V. Inhibition of Pathogens by L. acidophilus in Associative Culture...

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