Lactic acid bacteria engineering

Hugenholtz, J., and Kleerebezem, M. 1999. Metabolic engineering of lactic acid bacteria overview of the approaches and results of pathway rerouting involved in food fermentations. Curr. Op. Biotechnol., 10,492-497. 

Kleerebezemab, M., Hols, P., and Hugenholtz, J. 2000. Lactic acid bacteria as a cell factory rerouting of carbon metabolism in Lactococcus lactis by metabolic engineering. Enz. Microbial Technol., 26, 840-848. 

Nichols, N. N., Dien, B. S., and Bothast, R. J. 2003. Engineering lactic acid bacteria with pyruvate decarboxylase and alcohol dehydrogenase genes for ethanol production from Zymomonas mobilis. J. Ind. Microbiol. Biotechnol., 30, 315-321. 

Hoefnagel, M.H.N., Starrenburg, M.J.C., Martens, D.E., Hugenholtz, J., Kleerebezem, M., Van Swam, I.I., Bongers, R., Westerhoff, H.V. and Snoep, J.L. (2002) Metabolic engineering of lactic acid bacteria, the combined approach kinetic modelling, metabolic control and experimental analysis. Microbiology 148,1003-1013. 

Lactic acid bacteria are used to produce fermented milk products, and the exopolysaccharides produced by the bacteria influence the texture of the resulting products. More importantly, these exopolysaccharides are thought to have several health benefits. There is evidence they lower cholesterol, modulate the immune system, help prevent colon cancer, and fight ulcers [342,343]. There is thus interest in establishing stmcture-function relationships for these stmctures, as well as in metabolic engineering of lactic acid bacteria to produce capsular polysaccharides with the desired properties [342,343]. 

Genome sequence enables their engineering to produce better-tasting and safer foods such as Cheddar cheese and cabernet sauvignon Lactic acid bacteria [3]... 

Phage infection is still the principal problem faced by cheese makers. Mechanisms by which lactic acid bacteria resist phage infection are known and work is in progress to engineer strains with superior phage resistance. 

Papagianni, M (2012) Metabolic engineering of lactic acid bacteria for the production of industrially important compounds. Comput Struct. Biotechnol )., 3, 1-8,... 

Monedero, V., Perez-Martinez, G, and Yebra, M.J. (2010) Perspectives of engineering lactic acid bacteria for biotechnological polyol production. Appl Microbiol Biotechnol, 86, 1003-1015. 

Production of Oligosaccharides Using Engineered Bacteria Engineering of Exopolysaccharides from Lactic Acid Bacteria... 

Degeest, B., Vaningelgem, R, De Vuyst, L. (2001). Microbial physiology, fermentation kinetics, and process engineering of heteropolysaccharide production by lactic acid bacteria. International Dairy Journal, 11(9), 747-757. 

Systems biology and metabolic engineering of lactic acid bacteria for improved fermented foods... 

Metabolic engineering in industrial lactic acid bacteria (LAB)... 

Caspar, R, Carvalho, A. L., Vinga, S., Santos, H., Neves, A. R. (November 2013). From physiology to systems metabolic engineering for the production of biochemicals by lactic acid bacteria. Biotechnology Advances, 31(6), 764—788. 

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