Laboratory report preparation objectives

Emphasis is placed on preparing a validation protocol in which the specific validation experiments and associated acceptance criteria substantiate that the method meets its technical and regulatory objectives. Only after these steps does the process conclude with the performance of the formal validation and generation of the validation report. Finalization of method development (by way of the method validation) is never truly complete, as validation is aliving process that encompasses the ongoing use of the method in various laboratory settings. 

Many different types of control serum can be used for the purpose of fictitious patient controls. Depending on the method being evaluated, and the purpose of the control assessments, the authors have at various times used locally prepared pooled sera, commercial sera, and carry-over specimens from patients, and these together constitute the main present objective assessment of the quality of work that is being reported from this laboratory. When the results for the fictitious patient controls have been obtained, these are collected by the senior technician referred to above, recorded, charted, and analyzed (Section 3.3). 

The particular value of mechanical data-processing equipment and of computers in the rapid performance of statistical calculations based on laboratory data has been discussed (Section 3.3.4), as has their contribution to easing the burden of collecting data from measuring instruments, the performing of repetitive calculations, and the preparation of reports for laboratory work (Section 5.5). This section will consider the few examples that at present provide objective evidence for improvements in the reliability of laboratory work attributable to the introduction of modern data-processing equipment. 

Preparing, compiling, and presenting the information developed by a radioanalytical chemistry laboratory is not merely a clerical exercise it is fully as important as the analysis and measurement effort. The work must assure that the reported values meet the data quality objectives (see Section 11.3.1) in being reliable, providing... 

The main objective of analysis is to ensure the water supplied to the public meets the relevant standards and does not exceed the recommended concentration of hazardous chemicals. The analyses performed by the water laboratory for compliance purposes should be performed in an accredited laboratory and comply with the recognized standard for technical competence of testing laboratories. A complete analytical procedure should include information on sample handling (collection, transport, and storage), sample preparation (concentrate and separate), analysis (methods to identify and quantify components), analytical quality control (criteria), and reporting of analytical results. 

The basic requirements for the conduct of a vaMation and reporting of results are presented in this section. However, it must be emphasized that it is the responsibility of the analytical site to ensure that the necessary SOPs andotheriequired documents are in place before the initiation of work. In addition to the procedural practices which are described in the SOPs, a documented plan or protocol that describe the objectives, conduct and data reporting requirement should be prepared and approved by the responsible scientist, and preferably also by laboratory management. 

From the same laboratory, another report describes the use of this approach to prepare PPy/poly(alkyl methacrylate). In this case a chloroform solution of poly(alkyl methacrylate) and pyrrole is dispersed in an aqueous surfactant solution whereupon the oxidant is added. The PPy deposits on the host polymer and again a nonsolvent is used to precipitate the composite. The composites can then be hot-pressed to obtain films or other objects. Compared with cold-pressing, hot-pressing improves the mechanical properties but decreases the conductivities. In the hot-pressed materials, a distinct PPy phase could not be observed. 

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