Laboratory integration system

LBR solution butadiene rubber LIS laboratory integration system... 

A laboratory spectrosieter, Perkin-Elmer MPF-44B, is being used to acquire RTF data. Cyborg Corporation s Integrated System for Automatic Acquisition and Control and an Apple 11+ computer have been... 

The external review pointed up several types of occurrences that had to be addressed at the laboratories. In some cases, corrections had to be made, for example if elution peaks had been misidentifled or if the laboratory data system integrated noise and reported a peak where there was none. Such occurrences were observed primarily in the early stages of the study and decreased as the laboratories refined integration parameters for their individual commodities. In other cases, it became apparent that... 

A simple system is comprised of an isocratic pump, a manual injector, a UV detector, and a strip-chart recorder. A schematic diagram of an HPLC instrument is shown in Fig. 15.4. This simple configuration is rarely used in most modern laboratories. A typical HPLC system is likely to consist of a multi-solvent pump, an autosampler, an on-line degasser, a column oven, and a UV/Vis or photodiode array detector all connected to and controlled by a data-handling workstation. Examples of modular and integrated systems are shown in Fig. 15.5. Some of the important instrumental requirements are summarized in Table 15.2. 

The following recommendations represent integrated approaches to IQC that are suitable for many types of analysis and applications areas. Managers of laboratory quality systems will have to adapt the recommendations to the demands of their own particular requirements. Such adoption could be implemented, for example, by adjusting the number of duplicates and control material inserted into a run, or by the inclusion of any additional measures favoured in the particular application area. The procedure finally chosen and its accompanying decision rules must be... 

It is often the case that laboratories combine the use of equipment from more than one manufacturer into systems that need to be qualified. Each individual device must be qualified for the functionality of that device. Sometimes one manufacturer will sell and qualify other manufacturers devices that connect to their equipment. In this case, one company is responsible for the instrument qualifications of the entire integrated system. It is usually required that each manufacturer qualify its own device, and that following the qualification of the individual devices, the manufacturer that supplies the interface must then qualify the interfaces between the devices. 

Videl, L. L. and Christensen, I. J. (1990) A review of techniques and results obtained in one laboratory by an integrated system of methods designed for routine clinical flow cytometric DNA analysis. Cytometry 11, 753-770. 

Analytical. Samples were chromatographed on a Hewlett-Packard 5880A gas chromatograph which was fitted with a 30M fused silica capillary column (DBS) and an automatic sampler. The GC was interfaced to a Hewlett-Packard 3354 Laboratory Automation System (LAS). Raw data was automatically transferred to the LAS where peaks were selected by retention time, integrated and stored in a processed file. Processed data was then transferred... 

Analyses were done on a Dionex Model 14 Ion Chromatograph (IC), equipped with a Waters WISP 7 autosampler, Linear recorder, and interfaced with a Hewlett-Packard 3354 Laboratory Automated System. The principal components of the IC, shown in Figure 2, are (A) eluent reservoir, (B) pump, (C) injection valve, (D) separator column, (E) suppressor column, (F) conductivity cell, and (G) conductance meter with a recorder (integrator). 

The performance of an HPLC system can be evaluated by examining the key functions of the various modules that comprise the system, followed by holistic testing that challenges the performance of the HPLC components as an integrated system. The holistic testing is commonly referred to as the performance qualification (PQ). The holistic test can be as simple as running a frequently used HPLC method in the laboratory. Modular testing of various components, which is... 

ECONOMICS. Usually, the prime economic reason for buying an electronic integration system for a chromatography laboratory is to reduce operating costs. These reductions may be realized by both manpower or instrument savings immediately or over a long term. 

Solution. The laboratory coordinate system is used and there is no change in the overall specimen volume. The integral in Eq. 4.50 is proportional to the sum area 1 + area 2 in Fig. 4.7. Area 1 is positive and area 2 is negative. When x = 0 is set at the position of the original interface, area 2 is proportional to the amount of diffusant that has left... 

Schofield, chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, Mansfield Road, Oxford, U.K. 

In recent years robots and other automated instruments, and entire integrated systems, have been developed to accelerate the crystallization process (Luft et al., 2003 DeLucas et al., 2003 Hosfield et al., 2003 Bard et al., 2004). They have the capacity to screen thousands of crystallization conditions, and they do so precisely and reliably, with fewer errors and better record keeping than most humans. In many large laboratories these have become essential pieces of equipment. Using standard, usually commercially available screening kits, sometimes supplemented by local favorites, they can often arrive at acceptable crystals in the most expeditious possible manner. 

Integral to the automation of the clinical laboratory was the development of the laboratory information system (LIS) that first appeared in laboratories in the latter part of the... 

Computers and computer telecommunications are integral components of the entire analytical and reporting process and control the data input, operation, monitoring, and data reporting functions in automated analyzers. Also, workstations have been used to integrate the operation of one or more laboratory analyzers. Individual analyzers and/or their workstations are electronically interfaced with large central data repositories on laboratory information systems (LIS) and/or laboratory automation systems (LAS) (see Chapter 18). 

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