Knowledge creation procedure

In the sections that follow types of PK/PD knowledge creation, general steps in the knowledge creation process, data supplementation and the motivation for it, data supplementation procedure, nonparametric approximate Bayesian data supplementation method, structure-based multiple supplementation with a motivating example, and implications of the use of multiple data supplementation for the characterization of an unexplored region of the response are described. The emphasis in this chapter is on the use of data supplementation to characterize unexplored region of the response surface. A discussion on data synthesis, the qualitative characterization of the response surface, and the estimation of inestimable uncertainty has been elegantly presented by Williams et al. (1) and Ette and Onyiah (5). Therefore, these approaches are discussed in brief in the sections that follow. 

The modeling procedure described in Subsect. 2.4.2 addresses the work processes during the conceptual design of chemical processes. It covers the knowledge acquisition from stakeholders by means of field studies, the creation of conceptual semi-formal work process models, and their subsequent enrichment and formalization. The methodology has been successfully applied in several case studies conducted in industry (cf. Sect. 5.1). This modeling procedure is supposed to be extended... 

Use of fracture mechanics test methods for failure analysis of FRP composite elements is feasible, but to the best knowledge of the author, no examples of this have been published. The challenge here is mainly the preparation of suitable test specimens from structural elements and the creation of the starter cracks. ISO 15024 does provide some information on mode I starter crack preparation for nonstandard specimens in an informative appendix (B.8, Guidelines for wedge precracking ), and that procedure can be adapted for other specimen geometries. 

Procedures generate constraints to create an entity according to input information, or to maintain specified end surface conditions. The procedure for the creation of the selected entity has built-in knowledge for constraining. 

The procedure for the creation of knowledge-based 3D-CAD models is based on multifaceted types of representation which are implemented in leading CAD systems depending on the specific forms of knowledge (Fig. 10.6) and covers possibilities for action of the product designer in the knowledge-based model. The procedure consists of individually associated methods and operates based on the developed generic representation model (Fig. 10.7). 

We see queries and views as a means to express, respectively, specific questions relevant for argument structure creation, review, or modification, and their responses. Potential sources of queries, besides the experience of the safety engineer or the assessor, includes domain knowledge, such as that contained in regulations, standards, guidance documents, artifact documentation, documentation for processes and procedures, etc. To illustrate, we give some scenarios ... 

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