Kidneys niacin

Some drugs can cause hyperuricemia and gout, such as thiazide diuretics, niacin, pyrazinamide, cyclosporine, and occasionally, low-dose aspirin. In most cases, these drugs block uric acid secretion in the kidney. Long-term consequences of gout and hyperuricemia include joint destruction, tophi, and nephrolithiasis. 

Bioavailability of Niacin. Factors which cause a decrease in macm availability include (1) Cooking losses (2) bound form in corn (maize), greens, and seeds is only partially available (3) presence of oral antibiotics (4) diseases which may cause decreased absorption (5) decrease in tiyptophan conveision as in a vitamin B deficiency. Fac.tois that increase availability include (1) alkali treatment of cereals (2) storage in bver and possibly in muscle and kidney tissue and (3) increased intestinal synthesis. 

Liver and kidneys are excellent sources of vitamins A and B12, folate, niacin, iron, and other minerals... 

Good dietary sources of this vitamin are liver, kidney, lean meat, chicken, fish, wheat, barley, rye, green peas, yeast, peanuts, and leafy vegetables. In animal tissues, the predominant form of niacin is the amide. Niacin content of some foods are listed in Table 9-22. 

Vitamin requirements for ESKD patients receiving dialysis differ from those of a healthy person because of dietary modifications, kidney dysfunction, and dialysis therapy. The plasma concentrations of vitamins A and E are elevated in ESKD, while those of the water-soluble vitamins (81,82,8g, 812, niacin, pantothenic acid, folic acid, biotin, and vitamin C) tend to be low in this population, in large part due to the fact that many are dialyzable. The goal for vitamin supplementation in this population should be to prevent subclinical and frank deficiency and to avoid pathology from overdosage. Special vitamin supplements have been formulated for the dialysis population, which primarily include 8 vitamins with C and folic acid. 

From the above discussion it is possible to suggest that niacin has shown potential benefits in reducing inflammation in both animal models and human studies. However, It is not yet clear whether the effect of niacin in inflammation may have benefit in patients with chronic kidney disease (CKD). 

Niacin and Dyslipidaemia and Hyperphosphatemia with Chronic Kidney Disease... 

Niacin has shown potential benefit in treating both hyperphosphataemia and hyperlipidaemia associated with chronic kidney disease. 

Cho, K.H., Kim, H.J., Kamanna, V.S., and Vaziri, N.D., 2010. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Biochimica et Biophysica Acta. 1800 6 15. 

Rich sauren-TTie best lood sources of niacin are livet. kidney, lean meats, poultry, fish, rabbit, corn flakes lenrichedl. nuts, peanut butter. 

---