Ketones with other functional groups

Aldehydes or Ketones with Other Functional Groups Aldehydes, Ketones with Other Functional Groups Kepone Chlordecone Aliphatic Flydrocarbons Aliphatic Nitriles and Cyanates Acetonitrile Acrylonitrile Aliphatic Nitriles Aliphatic Nitrosamines Aliphatic Nitrosamines A-Nitrosodimethylamine (NDMA)... 

ALDEHYDES OR KETONES WITH OTHER FUNCTIONAL GROUPS... 

Aldehydes, Ketones with Other Functional Groups... 

Aldehydes, Ketones with Other Functional Groups under Aldehydes or Ketones with Other Functional Groups... 

Use of DMF as a solvent for the oxidation of l-o1efins has been reported by Clement and Selwitz. The method requires only a catalytic amount of PdCl2 and gives satisfactory yields under mild conditions. A small amount of olefin migration product is the only noticeable contaminant in the cases reported. The procedure can be applied satisfactorily to various 1-olefins with other functional groups. This useful synthetic method for the preparation of methyl ketones has been applied extensively in the syntheses of natural products such as steroids,macrolides, dihydrojasmone, and muscone. " A comprehensive review article on the palladium-catalyzed oxidation of olefins has... 

The majority of recent publications still deal with the chiral hydrogenation of ketones containing other functional groups as well. The general characteristics of these reactions are illustrated by the asymmetric hydrogenation of a./f-unsaturated ketones. In addition, the purpose of the present review is to summarize the latest results of the chiral hydrogenation of ketones which do not contain other functional groups (dialkyl ketones and alkyl aryl ketones). 

Related photochemistry has also been examined with other functional groups such as phthalimides, which also abstract nearby hydrogens with the photoexcited carbonyl group. - Furthermore, since the hydrogen abstraction is performed by the half-vacant nonbonding orbital of a photoexcited ketone carbonyl, related chemistry is observed if the electron is removed electrochemically, not just photoexcited into a Tr -orbital. Electrochemical functionalization of nearby carbons has been reported in which, after hydrogen atom abstraction by an oxidized ketone, the resulting radical is electrochemically oxidized further to the carbon cation, which reacts with solvent (Scheme 7). ... 

Tebbe s reagent, Cp2TiCH2Al(CH3)2Cl, converts carbonyl compounds to methy-lenes. This reagent when applied to ot,j6-unsturated aldehydes and ketones generates dienes (equation 106). Synthetic utility of the reagent for generation of dienes and polyenes is limited because of the difficulty in the preparation and incompatibility with other functional groups such as esters etc. 

E. Organolithium Reagents Reaction with Other Functional Groups The disconnection for ketone formation from the acid is ... 

It has been shown that addition of catalytic amounts of TBAF (0.02 equiv.) to A-(trimethylsilyl)imidazole promotes the quantitative silylation of alcohols in complex polyhydroxy compounds under milder conditions. The reaction proved to be highly chemos-elective, with other functional groups like ketones, enones, epoxides, amines or carboxylic acids being unreactive under these conditions. The silylation of a complex derivative that could not be achieved without TBAF was effected in 1 h (eq 1 ) ... 

Huonnations with DAST proceed with high chemoselectivity In general, under very mild reaction conditions usually required for the replacement of hydroxyl groups, other functional groups, including phenolic hydroxyl groups [112], remain intact This provides a method for selective conversion of hydroxy esters [95 97] (Table 6), hydroxy ketones [120, 121], hydroxy lactones [722, 123], hydroxy lactams [124] and hydroxy nitriles [725] into fluoro esters, fluoro ketones, fluoro lactones, fluoro lactams, and fluoro nitnles, respectively (equations 60-63)... 

Poly (ary lene ether sulfone)s and poly(arylene ether ketone) have been employed to prepare block and graft copolymers. Generally, the block copolymers can be prepared by reacting functional-group-terminated oligomers with other functional oligomers and monomers. 

A number of other reagents have been used to cleave C=N bonds, especially those not easily hydrolyzable with acidic or basic catalysts or which contain other functional groups that are attacked under these conditions. In particular, oximes have been converted to the corresponding aldehyde or ketone by treatment with, among other reagents, microwave irradiation on clay (Clayan), on wet sodium periodate... 

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