Kaneka

In a study aim to develop biocatalytic process for the synthesis of Kaneka alcohol, apotential intermediate for the synthesis of HMG-CoA reductase inhibitors, cell suspensions of Acine-tobacter sp. SC 13 874 was found to reduce diketo ethyl ester to give the desired syn-(AR,5S)-dihydroxy ester with an ee of 99% and a de of 63% (Figure 7.4). When the tert-butyl ester was used as the starting material, a mixture of mono- and di-hydroxy esters was obtained with the dihydroxy ester showing an ee of 87% and de of 51% for the desired, sy -(3/t,5,Sr)-dihydroxy ester [16]. Three different ketoreductases were purified from this strain. Reductase I only catalyzes the reduction of diketo ester to its monohydroxy products, whereas reductase II catalyzes the formation of dihydroxy products from monohydroxy substrates. A third reductase (III) catalyzes the reduction of diketo ester to, vv -(3/t,55)-dihydroxy ester. 

National Institute for Coastal and Marine Management/RIKZ Netherlands Institute for Fisheries Research OpdenKamp-Registration and Notification Wageningen University, Subdepartment of Toxicology Life Science Research Laboratories, Kaneka Corporation Flemish Institute for Technological Research Institute for Environmental Studies, Vrije Universiteit Amsterdam... 

T. Suzuki, Chlorinated vinyl chloride resin composition, US Patent 7332544, assigned to Kaneka Corporation (Osaka, JP), February 19, 2008. 

Minami M, Toya T, Katao Y, Maekawa K, Nakamura S, Onogi T, Kaneka S, Satoh M. FEBS Lett 1993 329 291-295. 

Oohara, Y. Hirose, F. Sato, T. et al. Extruded styrene resin foam and process for producing the same, US Patent 6,762,212 to Kaneka Corporation, 2004. 

Stuart, J.B. Skarke, S.C. Ogita, T. et al. Flame retardant polyolefin resin pre-expanded particles and in-mold foamed articles prepared therefrom, PCT US Patent 6,822,023 assigned to Kaneka Corporation, 2001. 

ISRAEL CHEMICALS LTD ITOCHU CORP JM HUBER CORPORATION JSR CORPORATION KANEKA CORPORATION KAO CORPORATION KBRINC KEMIRA OYJ KEY PLASTICS LLC... 

BEHR Process Corporation MASTERCHEM INDUSTRIES LLC Belclene BWA WATER ADDITIVES Belco KANEKA CORPORATION Belgard BWA WATER ADDITIVES Bellacide BWA WATER ADDITIVES Bellasol BWA WATER ADDITIVES Belsperse BWA WATER ADDITIVES Bemis Clysar, BEMIS COMPANY INC Bemis Company, Inc. CURWOOD INC... 

KANEPEARL PLA foam (Agri-/ Horticultural materials) PLA KANEKA... 

In 2005, Japanese company Kaneka developed the first beads-process, foamed resin moulded product, which is based on polylactic acid. The new KanePearl product has the strength and shock-absorbing properties of existing beads-process, foamed polystyrene products. 

In 2004, Procter Gamble formed a joint development agreement with Japan s Kaneka Corporation for the commercialisation of Nodax biodegradable polymers. The companies will develop cost-effective ways of producing Nodax through fermentation and make the polymer easier to process so it can be used in a wider range of applications. 

The enzymes of the nucleic acid metabolism are used for several industrial processes. Related to the nucleobase metabolism is the breakdown of hydantoins. The application of these enzymes on a large scale has recently been reviewed [85]. The first step in the breakdown of hydantoins is the hydrolysis of the imide bond. Most of the hydantoinases that catalyse this step are D-selective and they accept many non-natural substrates [78, 86]. The removal of the carbamoyl group can also be catalysed by an enzyme a carbamoylase. The D-selective carbamoylases show wide substrate specificity [85] and their stereoselectivity helps improving the overall enantioselectivity of the process [34, 78, 85]. Genetic modifications have made them industrially applicable [87]. Fortunately hydantoins racemise readily at pH >8 and additionally several racemases are known that can catalyze this process [85, 88]. This means that the hydrolysis of hydantoins is always a dynamic kinetic resolution with yields of up to 100% (Scheme 6.25). Since most hydantoinases are D-selective the industrial application has so far concentrated on D-amino acids. Since 1995 Kaneka Corporation has produced 2000 tons/year of D-p-hydroxyphenylglycine with a D-hydantoinase, a d-carbamoylase [87] and a base-catalysed racemisation [85, 89]. 

Takaki A Narisawa I Kuriyama T KANEKA Corp. Yamagata,University... 

Nishimura R Silbermann J Nakanishi Y Kaneka Texas Corp. Kaneka Corp. 

Miki Y Nakanishi Y Takaki A Yamazaki K Kaneka Corp. 

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