Acine-tobacter

Livermore DM, Woodford N (2006) The (3-lactamase threat in Enterobacteriaceae, Pseudomonas and Acine-tobacter. Trends Microbiol 14(9) 413—420... 

In a study aim to develop biocatalytic process for the synthesis of Kaneka alcohol, apotential intermediate for the synthesis of HMG-CoA reductase inhibitors, cell suspensions of Acine-tobacter sp. SC 13 874 was found to reduce diketo ethyl ester to give the desired syn-(AR,5S)-dihydroxy ester with an ee of 99% and a de of 63% (Figure 7.4). When the tert-butyl ester was used as the starting material, a mixture of mono- and di-hydroxy esters was obtained with the dihydroxy ester showing an ee of 87% and de of 51% for the desired, sy -(3/t,5,Sr)-dihydroxy ester [16]. Three different ketoreductases were purified from this strain. Reductase I only catalyzes the reduction of diketo ester to its monohydroxy products, whereas reductase II catalyzes the formation of dihydroxy products from monohydroxy substrates. A third reductase (III) catalyzes the reduction of diketo ester to, vv -(3/t,55)-dihydroxy ester. 

Rosenberg, M. and Rosenberg, E. (1981). Role of adherence in growth of Acine-tobacter cacoaceticus RAG-1 on hexadecane, J. Bacteriol, 148, 51-57. 

Two microbial FDPases have been described which are unusual in their lack of inhibition by AMP. A species of gram-negative Acine-tobacter is inhibited by ATP and citrate, but not by AMP, suggesting... 

There are no vaccines against bacteria such as Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Clostridium difficile and Acine-tobacter baumannii, which together are responsible for the majority of nosocomial infections, ranging from septicemia to pneumonia and... 

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