Junctional adhesion molecule

Yet another family of junction adhesion molecules (JAMs) was recently located at the tight junctions of both endothelial and epithelial cells. The intracellular domain of JAM-1 also interacts with structural and signaling proteins, such as ZO-1 and cingulin. Lastly, the molecular organization of the endothelial cell junctions includes two other cell-cell contact Ca2+-dependent cadherin-catenin systems. These make up the adherens junction common to all endothelial cell junctions. 

Mercier, G. T., Campbell, J. A., Chappell, J. D., Stehle, T., Dermody, T. S., and Barry, M. A. (2004). A chimeric adenovirus vector encoding reovirus attachment protein sigmal targets cells expressing junctional adhesion molecule 1. Proc. Natl. Acad. Sci. USA 101, 6188-6193. 

Martin-Padura I, Lostaglio S, Schneemann M, Williams L, Romano M, Fruscella P, Panzeri C, Stoppacciaro A, Ruco L, Villa A, Simmons D, and Dejana E [1998] Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol 142 117-127... 

Naik UR Eckfeld K. Junctional adhesion molecule I (JAM-1). J Biol Regul Homeost Agents 2003 17 341-347. 

Chavakis T Keiper T, Matz-Westphal R, et al, The junctional adhesion molecule-C promotes neutrophil transendothelia I migration in vitro and in vivo. J Biol Chem 2004 279 55602-55608. 

The TJPs form an intricate complex of transmembrane (occludin, claudins, junctional adhesion molecule-1) and cytoplasmic (zona occludens-1 and -2, cingulin, AF-6, and 7H6) proteins linked to the cytoskeleton (Hawkins and Davis, 2005) (Fig. 1). Occludin was the first TJP discovered. It is a 60- to 65-kDa protein with four transmembrane domains and two extracellular loops that span the cleft between adjacent endothelial cells (Furuse et al., 1993 Hirase et al., 1997 Hawkins and Davis, 2005). Occludin is highly expressed in cerebral endothelium (Fig. 2) and sparsely distributed in nonneural endothelia (Hirase et al., 1997). The phosphorylation state of occludin regulates its association with the cell membrane (Hirase et al., 2001). In experimental autoimmune encephalomyelitis, a model of multiple sclerosis, occludin dephosphorylation precedes the neurological deterioration and increased leakage of plasma proteins across the BBB (Morgan et al., 2007). The C-terminal cytoplasmic domain of occludin is involved in its association with the cytoskeleton via accessory proteins such as zona occludens ZO-1 and ZO-2 (Furuse et al, 1993). 

Oligomerization state switches in alphaviruses, 367-370 in flaviviruses, 367-370 (t1 head, junction adhesion molecule and, 482-483... 

Shaw SK, Perkins BN, LimYC, LiuY, Nusrat A, Schnell FJ, Parkos CA, Luscinskas FW Reduced e q)ression of junctional adhesion molecule and platelet/endothelial cell adhesion molecule-1 (CD31) at human vascular endothelial junctions by cytokines tumor necrosis factor-alpha plus interferon-gamma does not reduce leukocyte transmigration under flow. Am J Pathol 2001 ... 

The claimed health-promoting activities exerted by bifidobacteria are numerous, and include establishment of a healthy microbiota in preterm infants, cholesterol reduction, lactose intolerance, prevention of infectious diarrhea, prevention of cancer, protection against infectious diseases, modulation of mucosal barrier function, amino acid and vitamin production, inhibition of nitrate reduction, stimulation of calcium uptake by enterocytes, short-chain fatty acid production, stimulation of intestinal epithelia through induction of anti-inflammatory c5dokine interleukin (IL)-IO and junctional adhesion molecules. ... 

Prota AE, Campbell JA, Schelling P, Forrest JC, Watson MJ, Peters TR, Aurrand-Lions M, Imhof BA, Dermody TS, Stehle T (2003) Crystal stmcture of human junctional adhesion molecule 1 implications for reovims binding. Proc Natl Acad Sci U S A 100 5366-5371... 

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