Janssen Pharmaceuticals

This second-generation histamine HI receptor blocker was put on the world market in the 1980s for the relief of symptoms associated with seasonal allergic rhinitis and chronic idiopathic urticaria [14], Janssen Pharmaceuticals marketed this dmg under the brand name Hismanal. The major benefit of these antihistamines was their... 

Fentanyl was introduced to the United States in 1968 by the Janssen Pharmaceutical Company and marketed under the trade name Sublimaze. Its primary purpose was for use as an intravenous anesthetic and analgesic. It is 100 times more potent than morphine in reducing pain, and its duration of action is only 30 minutes (compared to morphine, which lasts several hours). Over the years, fentanyl has proved to be an extremely useful drug, and to date, it is still widely used for surgeries, childbirth, pain associated with cancer and other diseases, and the treatment of trauma-related injuries. Although fentanyl solutions are often given intravenously, pill forms of the drug are also available. 

Cisapride monohydrate Propulsid Janssen Pharmaceuticals Heartburn 7/29/1993 7/14/2000 7 years Heart rhythm abnormalities US 2.5 billion... 

Asternizole Hismanal Janssen Pharmaceuticals Antihistamine 12/19/1988 5/18/1999 6 months Heart rhythm abnormalities 23 million... 

Risperdal Risperidone 0.25, 0.5, 1, 2, 3, 4 mg Tablet Schizophrenia A selective monoaminergic antagonist (5HT2, dopamine type 2 (D2), al and a2 adrenergic, and HI histaminergic receptors Colloidal silicon dioxide, hypromellose, lactose, magnesium stearate, MCC, propylene glycol, sodium lauryl sulfate, corn starch Janssen Pharmaceuticals... 

Hypnorm (0.315 mg/mL fentanyl citrate and 10 mg/mL fluanisone Janssen Pharmaceutical Ltd., Grove, Oxford, UK). 

And while it is also true that thirty pharmaceutical companies alone account for 60 percent of worldwide ethical drug sales, the sums of money invested in research do not always get their full return. Thus it is that a small company like Janssen s laboratory, Janssen Pharmaceuticals, in Belgium, which was acquired in 1979 by Johnson and Johnson and which has among its discoveries diphenoxylate (1963) and loperamide (1975), has proved more innovative over the last fifteen years than the Rhone-Poulenc group, which has produced no major new molecule during the same time, although it devotes far more money to its research. 

Sporanox , itraconazole [package insert]. Titusville, NJ Janssen Pharmaceutical Products, L.P. (package insert revised 1/2004). 

Table 1-4 contains the Information that could be obtained on the single-dose lethal activities of the two substances In this group, bensetlmlde and meplperphenldol. Information on the toxlcltles of these compounds was supplied by Janssen Pharmaceutics and Sharp and Dohme Institute for Medical Research, respectively. Benzetlmlde Is 2-(I benzy1-4-plperldyl)-2-phenylglutarlmlde, and meplperphenldol Is l-(3-hydroxy-4-phenyl-5-me thyIhexy1)-l-methyIplperldlnlum bromide. 

Also known by its trade name Bethoguard from the producer Janssen pharmaceuticals, it has been promoted by companies like Ackros, with their grades Intercide BTX (Figure 39). 

Johnson Johnson Pharmaceutical Research and Development A Division of Janssen Pharmaceutics N.V. 

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